Proteins/UNIPROT:O14950

MYL12B

ProteinUNIPROT:O14950

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion..

Function from UniProtKB (O14950), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

46 statements

46 statements · 3 reference databases · Subject: MYL12B · Sources: Hetionet, Reactome, WikiPathways

Order

MYL12B covaries with DACT1ProteinHetionet hetionet:covaries:103910-51339Inferred only
DUSP28 covaries with MYL12BProteinHetionet hetionet:covaries:103910-285193Inferred only
MYL12B covaries with P2RY6ProteinHetionet hetionet:covaries:103910-5031Inferred only
MYL12B covaries with PHLDA3ProteinHetionet hetionet:covaries:103910-23612Inferred only
PURB covaries with MYL12BProteinHetionet hetionet:covaries:103910-5814Inferred only
MYL12B covaries with RPLP2ProteinHetionet hetionet:covaries:103910-6181Inferred only
TMEM229A covaries with MYL12BProteinHetionet hetionet:covaries:103910-730130Inferred only
XKR6 covaries with MYL12BProteinHetionet hetionet:covaries:103910-286046Inferred only
ACTB interacts with MYL12BProteinHetionet hetionet:interacts:103910-60Inferred only
ARRB1 interacts with MYL12BProteinHetionet hetionet:interacts:103910-408Inferred only
CDK2 interacts with MYL12BProteinHetionet hetionet:interacts:1017-103910Inferred only
CUL1 interacts with MYL12BProteinHetionet hetionet:interacts:103910-8454Inferred only

Show the remaining 34

DAPK1 interacts with MYL12BProteinHetionet hetionet:interacts:103910-1612Inferred only
ITGA4 interacts with MYL12BProteinHetionet hetionet:interacts:103910-3676Inferred only
MYH11 interacts with MYL12BProteinHetionet hetionet:interacts:103910-4629Inferred only
MYLIP interacts with MYL12BProteinHetionet hetionet:interacts:103910-29116Inferred only
PCLAF interacts with MYL12BProteinHetionet hetionet:interacts:103910-9768Inferred only
PNKD interacts with MYL12BProteinHetionet hetionet:interacts:103910-25953Inferred only
SUMO2 interacts with MYL12BProteinHetionet hetionet:interacts:103910-6613Inferred only
UBC interacts with MYL12BProteinHetionet hetionet:interacts:103910-7316Inferred only
MYL12B participates in Axon guidancePathwayWikiPathways WP5289Inferred only
MYL12B participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
MYL12B participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
MYL12B participates in EPH-Ephrin signalingPathwayReactome R-HSA-2682334Inferred only
MYL12B participates in EPHA-mediated growth cone collapsePathwayReactome R-HSA-3928663Inferred only
MYL12B participates in Focal adhesionPathwayWikiPathways WP306Inferred only
MYL12B participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
MYL12B participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
MYL12B participates in RHO GTPase EffectorsPathwayReactome R-HSA-195258Inferred only
MYL12B participates in RHO GTPases activate CITPathwayReactome R-HSA-5625900Inferred only
MYL12B participates in RHO GTPases activate PAKsPathwayReactome R-HSA-5627123Inferred only
MYL12B participates in RHO GTPases activate PKNsPathwayReactome R-HSA-5625740Inferred only
MYL12B participates in RHO GTPases Activate ROCKsPathwayReactome R-HSA-5627117Inferred only
MYL12B participates in Sema4D in semaphorin signalingPathwayReactome R-HSA-400685Inferred only
MYL12B participates in Sema4D induced cell migration and growth-cone collapsePathwayReactome R-HSA-416572Inferred only
MYL12B participates in Semaphorin interactionsPathwayReactome R-HSA-373755Inferred only
MYL12B participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
MYL12B participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
MYL12B participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
MYL12B participates in Smooth Muscle ContractionPathwayReactome R-HSA-445355Inferred only
MYL12B participates in Thyroid stimulating hormone TSH signalingPathwayWikiPathways WP2032Inferred only
ALDH7A1 decreases the expression of MYL12BProteinHetionet hetionet:regulates:501-103910Inferred only
DEK decreases the expression of MYL12BProteinHetionet hetionet:regulates:7913-103910Inferred only
KLF6 increases the expression of MYL12BProteinHetionet hetionet:regulates:1316-103910Inferred only
MACF1 decreases the expression of MYL12BProteinHetionet hetionet:regulates:23499-103910Inferred only
POLB decreases the expression of MYL12BProteinHetionet hetionet:regulates:5423-103910Inferred only

Other names

9 names

Resolves to: MYL12B

Also called: MLC-2MLC-2AMLC20MRLC2MYLC2BMyosin regulatory light chain 2-B, smooth muscle isoformMyosin regulatory light chain 20 kDaMyosin regulatory light chain MRLC2SHUJUN-1

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