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Proteins/UNIPROT:Q96FI4
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC..
Function from UniProtKB (Q96FI4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 3 reference databases · Subject: NEIL1 · Sources: Hetionet, Reactome, WikiPathways
1 reaction
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNAa 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA+a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA+hydron
Catalysed by OGG1 or POLB or XRCC6 or XRCC5 or RPS3 or NTHL1 or ALKBH1 or NEIL3 or NEIL2 or NEIL1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:66592CC BY 4.0Reference data
7 names
Resolves to: NEIL1