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Proteins/UNIPROT:Q969V6
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus..
Function from UniProtKB (Q969V6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
37 statements
37 statements · 3 reference databases · Subject: MRTFA · Sources: gene ontology, Hetionet, Reactome
7 names
Resolves to: MRTFA