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Proteins/UNIPROT:Q8TAT5
DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues..
Function from UniProtKB (Q8TAT5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
55 statements
55 statements · 3 reference databases · Subject: NEIL3 · Sources: Hetionet, Reactome, WikiPathways
1 reaction
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNAa 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA+a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA+hydron
Catalysed by OGG1 or POLB or XRCC6 or XRCC5 or RPS3 or NTHL1 or ALKBH1 or NEIL3 or NEIL2 or NEIL1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:66592CC BY 4.0Reference data
4 names
Resolves to: NEIL3