Loading the page.
Proteins/UNIPROT:P49281
Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1. Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity). Can mediate uncoupled fluxes of either protons or metal ions..
Function from UniProtKB (P49281), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · transported by
3 compounds
3 compounds.
0 reported routes3 assembled routes
1 row
123 statements
123 statements · 6 reference databases · Subject: SLC11A2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
10 reactions
8 names
Resolves to: SLC11A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05989CC BY 4.0Reference data
Transported by SLC11A2 or MCOLN2 or SLC25A28 or SLC41A2 or MCOLN1 or SLC40A1 or SLC25A37
Reaction pageDirection not assertedBalanced
Rhea RHEA:28486CC BY 4.0Reference data
Transported by SLC11A2
Reaction pageReversibleBalanced
Rhea RHEA:29007CC BY 4.0Reference data
iron(2+)+hydroniron(2+)+hydron
Transported by SLC11A2
Reaction pageReversibleBalanced
Rhea RHEA:29579CC BY 4.0Reference data
Transported by SLC25A14 or SLC25A27 or MT-ATP6 or SLC25A5 or ATP5MC1 or SLC25A4 or SLC25A6 or UCP1 or SLC11A2 or UCP2 or SLC25A11 or OTOP3 and 6 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:34979CC BY 4.0Reference data
Transported by SLC11A2
Reaction pageLeft to rightBalanced
Rhea RHEA:71195CC BY 4.0Reference data
Transported by SLC11A2
Reaction pageLeft to rightBalanced
Rhea RHEA:73031CC BY 4.0Reference data
Transported by SLC11A2
Reaction pageLeft to rightBalanced
Rhea RHEA:73035CC BY 4.0Reference data
Transported by SLC11A2
Reaction pageLeft to rightBalanced
Rhea RHEA:73039CC BY 4.0Reference data