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Proteins/UNIPROT:P39060
Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube..
[Non-collagenous domain 1]: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling..
[Endostatin]: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1..
Function from UniProtKB (P39060), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
32 statements
32 statements · 3 reference databases · Subject: COL18A1 · Sources: gene ontology, Hetionet, Reactome
3 names
Resolves to: COL18A1