Loading the page.
Proteins/UNIPROT:O15054
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity)..
Function from UniProtKB (O15054), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
94 statements
94 statements · 7 reference databases · Subject: KDM6B · Sources: gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea, UniProt, WikiPathways
1 reaction
N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3]+22-oxoglutarate(2-)+2dioxygenN(6)-methyl-L-lysyl(27)-[histone H3]+2formaldehyde+2succinate(2-)+2carbon dioxide
Catalysed by UTY or KDM6B or KDM6A
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60224CC BY 4.0Reference data
6 names
Resolves to: KDM6B