Proteins/UNIPROT:P31629

HIVEP2

ProteinUNIPROT:P31629

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.

Function from UniProtKB (P31629), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

autosomal dominant non-syndromic intellectual disability has a germline basis in HIVEP2DiseaseGenCC HGNC:4921|MONDO:0015802Inferred only
intellectual disability, autosomal dominant 43 has a germline basis in HIVEP2DiseaseGenCC HGNC:4921|MONDO:0014858Inferred only

Statements

21 statements

21 statements · 3 reference databases · Subject: HIVEP2 · Sources: gene ontology, Hetionet, WikiPathways

Order

HIVEP2 covaries with CRXProteinHetionet hetionet:covaries:1406-3097Inferred only
HIVEP2 covaries with H2BC4; H2BC6; H2BC7; H2BC8; H2BC10ProteinHetionet hetionet:covaries:3097-8339Inferred only
HIVEP2 covaries with RFNGProteinHetionet hetionet:covaries:3097-5986Inferred only
HIVEP2 interacts with RAC3ProteinHetionet hetionet:interacts:3097-5881Inferred only
HIVEP2 interacts with RFX1ProteinHetionet hetionet:interacts:3097-5989Inferred only
HIVEP2 interacts with UBCProteinHetionet hetionet:interacts:3097-7316Inferred only
HIVEP2 interacts with WNK1ProteinHetionet hetionet:interacts:3097-65125Inferred only
HIVEP2 interacts with YWHAEProteinHetionet hetionet:interacts:3097-7531Inferred only
HIVEP2 interacts with YWHAGProteinHetionet hetionet:interacts:3097-7532Inferred only
HIVEP2 interacts with YWHAZProteinHetionet hetionet:interacts:3097-7534Inferred only
HIVEP2 participates in Rett syndromePathwayWikiPathways WP4312Inferred only
HIVEP2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P31629|GO:0006357Inferred only

Show the remaining 9

B4GALT3 increases the expression of HIVEP2ProteinHetionet hetionet:regulates:8703-3097Inferred only
CALR increases the expression of HIVEP2ProteinHetionet hetionet:regulates:811-3097Inferred only
DAXX increases the expression of HIVEP2ProteinHetionet hetionet:regulates:1616-3097Inferred only
DNMT1 increases the expression of HIVEP2ProteinHetionet hetionet:regulates:1786-3097Inferred only
MAP2K6 increases the expression of HIVEP2ProteinHetionet hetionet:regulates:5608-3097Inferred only
NDUFA5 increases the expression of HIVEP2ProteinHetionet hetionet:regulates:4698-3097Inferred only
NSDHL increases the expression of HIVEP2ProteinHetionet hetionet:regulates:50814-3097Inferred only
PNKP increases the expression of HIVEP2ProteinHetionet hetionet:regulates:11284-3097Inferred only
TIMP2 increases the expression of HIVEP2ProteinHetionet hetionet:regulates:7077-3097Inferred only

Other names

4 names

Resolves to: HIVEP2

Also called: HIV-EP2Human immunodeficiency virus type I enhancer-binding protein 2MBP-2MHC-binding protein 2

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