Proteins/UNIPROT:Q9UKT9

IKZF3

ProteinUNIPROT:Q9UKT9

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner..

Function from UniProtKB (Q9UKT9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

immunodeficiency 84 has a germline basis in IKZF3DiseaseGenCC HGNC:13178|MONDO:0030333Inferred only

Statements

35 statements

35 statements · 4 reference databases · Subject: IKZF3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

FBN3 covaries with IKZF3ProteinHetionet hetionet:covaries:22806-84467Inferred only
LIMD1 covaries with IKZF3ProteinHetionet hetionet:covaries:22806-8994Inferred only
ALOX5 interacts with IKZF3ProteinHetionet hetionet:interacts:22806-240Inferred only
IKZF3 interacts with ATPAF2ProteinHetionet hetionet:interacts:22806-91647Inferred only
BCL2L1 interacts with IKZF3ProteinHetionet hetionet:interacts:22806-598Inferred only
CDKN2D interacts with IKZF3ProteinHetionet hetionet:interacts:1032-22806Inferred only
CHD3 interacts with IKZF3ProteinHetionet hetionet:interacts:1107-22806Inferred only
IKZF3 interacts with FOXP3ProteinHetionet hetionet:interacts:22806-50943Inferred only
HRAS interacts with IKZF3ProteinHetionet hetionet:interacts:22806-3265Inferred only
IKZF1 interacts with IKZF3ProteinHetionet hetionet:interacts:10320-22806Inferred only
IKZF3 interacts with IKZF4ProteinHetionet hetionet:interacts:22806-64375Inferred only
IKZF3 interacts with IKZF5ProteinHetionet hetionet:interacts:22806-64376Inferred only

Show the remaining 23

IL2 interacts with IKZF3ProteinHetionet hetionet:interacts:22806-3558Inferred only
IKZF3 interacts with LDOC1ProteinHetionet hetionet:interacts:22806-23641Inferred only
IKZF3 interacts with MAGOHBProteinHetionet hetionet:interacts:22806-55110Inferred only
PRKAB2 interacts with IKZF3ProteinHetionet hetionet:interacts:22806-5565Inferred only
RBBP8 interacts with IKZF3ProteinHetionet hetionet:interacts:22806-5932Inferred only
IKZF3 interacts with RCOR3ProteinHetionet hetionet:interacts:22806-55758Inferred only
IKZF3 interacts with TEKT4ProteinHetionet hetionet:interacts:150483-22806Inferred only
UBC interacts with IKZF3ProteinHetionet hetionet:interacts:22806-7316Inferred only
UBE2I interacts with IKZF3ProteinHetionet hetionet:interacts:22806-7329Inferred only
IKZF3 participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only
IKZF3 participates in ATP-dependent chromatin remodelersPathwayReactome R-HSA-9932444Inferred only
IKZF3 participates in CHD chromatin remodelersPathwayReactome R-HSA-9937848Inferred only
IKZF3 participates in CHD3, CHD4, CHD5 subfamilyPathwayReactome R-HSA-9943965Inferred only
IKZF3 participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
IKZF3 participates in Interaction of NuRD complexes with transcription factorsPathwayReactome R-HSA-9940951Inferred only
IKZF3 participates in NuRD complex assemblyPathwayReactome R-HSA-9937850Inferred only
IKZF3 regulates regulation of apoptotic processBiological processgene ontology Q9UKT9|GO:0042981Inferred only
IKZF3 regulates regulation of B cell differentiationBiological processgene ontology Q9UKT9|GO:0045577Inferred only
IKZF3 regulates regulation of B cell proliferationBiological processgene ontology Q9UKT9|GO:0030888Inferred only
IKZF3 regulates regulation of lymphocyte differentiationBiological processgene ontology Q9UKT9|GO:0045619Inferred only
IKZF3 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9UKT9|GO:0006357Inferred only
IKZF3 increases the expression of PNKPProteinHetionet hetionet:regulates:22806-11284Inferred only
IKZF3 decreases the expression of UBR7ProteinHetionet hetionet:regulates:22806-55148Inferred only

Other names

3 names

Resolves to: IKZF3

Also called: Ikaros family zinc finger protein 3Zinc finger protein AiolosZNFN1A3

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