Proteins/UNIPROT:O15084

ANKRD28

ProteinUNIPROT:O15084

Regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. Involved in the PP6-mediated dephosphorylation of MOB1 and induced focal adhesion assembly during cell migration..

Function from UniProtKB (O15084), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

52 statements

52 statements · 3 reference databases · Subject: ANKRD28 · Sources: gene ontology, Hetionet, Reactome

Order

H2AC1 covaries with ANKRD28ProteinHetionet hetionet:covaries:221613-23243Inferred only
ABCF2 interacts with ANKRD28ProteinHetionet hetionet:interacts:10061-23243Inferred only
AGPAT2 interacts with ANKRD28ProteinHetionet hetionet:interacts:10555-23243Inferred only
ANK2 interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-287Inferred only
ANKRD28 interacts with ANKFY1ProteinHetionet hetionet:interacts:23243-51479Inferred only
ANKRD26 interacts with ANKRD28ProteinHetionet hetionet:interacts:22852-23243Inferred only
ANKRD28 interacts with ANKRD50ProteinHetionet hetionet:interacts:23243-57182Inferred only
BCL3 interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-602Inferred only
CD164 interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-8763Inferred only
CSNK2B interacts with ANKRD28ProteinHetionet hetionet:interacts:1460-23243Inferred only
DOCK1 interacts with ANKRD28ProteinHetionet hetionet:interacts:1793-23243Inferred only
EEF1G interacts with ANKRD28ProteinHetionet hetionet:interacts:1937-23243Inferred only

Show the remaining 40

EHMT2 interacts with ANKRD28ProteinHetionet hetionet:interacts:10919-23243Inferred only
HNRNPK interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-3190Inferred only
HNRNPR interacts with ANKRD28ProteinHetionet hetionet:interacts:10236-23243Inferred only
MYOM1 interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-8736Inferred only
NCL interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-4691Inferred only
NFKBIE interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-4794Inferred only
NOTCH2 interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-4853Inferred only
NOTCH3 interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-4854Inferred only
ANKRD28 interacts with RNF11ProteinHetionet hetionet:interacts:23243-26994Inferred only
TGM2 interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-7052Inferred only
ANKRD28 interacts with TGS1ProteinHetionet hetionet:interacts:23243-96764Inferred only
TNKS interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-8658Inferred only
ANKRD28 interacts with TNKS2ProteinHetionet hetionet:interacts:23243-80351Inferred only
TTN interacts with ANKRD28ProteinHetionet hetionet:interacts:23243-7273Inferred only
ANKRD28 interacts with UACAProteinHetionet hetionet:interacts:23243-55075Inferred only
ANKRD28 interacts with ZNF512BProteinHetionet hetionet:interacts:23243-57473Inferred only
ANKRD28 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
ANKRD28 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
ANKRD28 participates in Chromosome MaintenancePathwayReactome R-HSA-73886Inferred only
ANKRD28 participates in COPII-mediated vesicle transportPathwayReactome R-HSA-204005Inferred only
ANKRD28 participates in ER to Golgi Anterograde TransportPathwayReactome R-HSA-199977Inferred only
ANKRD28 participates in Extension of TelomeresPathwayReactome R-HSA-180786Inferred only
ANKRD28 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
ANKRD28 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ANKRD28 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ANKRD28 participates in Telomere Extension By TelomerasePathwayReactome R-HSA-171319Inferred only
ANKRD28 participates in Telomere MaintenancePathwayReactome R-HSA-157579Inferred only
ANKRD28 participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
ANKRD28 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
ANKRD28 regulates positive regulation of focal adhesion assemblyBiological processgene ontology O15084|GO:0051894Inferred only
HDAC6 increases the expression of ANKRD28ProteinHetionet hetionet:regulates:10013-23243Inferred only
MAP3K7 decreases the expression of ANKRD28ProteinHetionet hetionet:regulates:6885-23243Inferred only
NSDHL increases the expression of ANKRD28ProteinHetionet hetionet:regulates:50814-23243Inferred only
PCK2 increases the expression of ANKRD28ProteinHetionet hetionet:regulates:5106-23243Inferred only
PNKP increases the expression of ANKRD28ProteinHetionet hetionet:regulates:11284-23243Inferred only
PRCP increases the expression of ANKRD28ProteinHetionet hetionet:regulates:5547-23243Inferred only
RBBP6 increases the expression of ANKRD28ProteinHetionet hetionet:regulates:5930-23243Inferred only
SETMAR increases the expression of ANKRD28ProteinHetionet hetionet:regulates:6419-23243Inferred only
STAT5A decreases the expression of ANKRD28ProteinHetionet hetionet:regulates:6776-23243Inferred only
SWAP70 increases the expression of ANKRD28ProteinHetionet hetionet:regulates:23075-23243Inferred only

Other names

6 names

Resolves to: ANKRD28

Also called: Ankyrin repeat domain-containing protein 28KIAA0379Phosphatase interactor targeting protein hnRNP KPITKPP6-ARS-ASerine/threonine-protein phosphatase 6 regulatory subunit ARS-A

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