Proteins/UNIPROT:P68871

HBB

ProteinUNIPROT:P68871

Involved in oxygen transport from the lung to the various peripheral tissues..

LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.

[Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.

Function from UniProtKB (P68871), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

21 rows · Showing 12

beta thalassemia has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0019402Inferred only
beta-thalassemia and related diseases has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0017145Inferred only
beta-thalassemia HBB/LCRB has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0013517Inferred only
beta-thalassemia intermedia has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0016487Inferred only
beta-thalassemia major has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0016486Inferred only
delta-beta-thalassemia has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0016489Inferred only
dominant beta-thalassemia has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0011381Inferred only
erythrocytosis, familial, 6 has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0054801Inferred only
Heinz body anemia has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0007705Inferred only
hemoglobin C disease has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0016242Inferred only
hemoglobin C-beta-thalassemia syndrome has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0016490Inferred only
hemoglobin E disease has a germline basis in HBBDiseaseGenCC HGNC:4827|MONDO:0016243Inferred only

Statements

119 statements

119 statements · 4 reference databases · Subject: HBB · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CDK2 interacts with HBBProteinHetionet hetionet:interacts:1017-3043Inferred only
HBA1; HBA2 interacts with HBBProteinHetionet hetionet:interacts:3040-3043Inferred only
HBA1; HBA2 interacts with HBBProteinHetionet hetionet:interacts:3039-3043Inferred only
HBB interacts with HBG2ProteinHetionet hetionet:interacts:3043-3048Inferred only
HBB interacts with HBZProteinHetionet hetionet:interacts:3043-3050Inferred only
HBB interacts with HPProteinHetionet hetionet:interacts:3043-3240Inferred only
HBB interacts with UBCProteinHetionet hetionet:interacts:3043-7316Inferred only
HBB interacts with UCHL5ProteinHetionet hetionet:interacts:3043-51377Inferred only
HBB participates in AutophagyPathwayReactome R-HSA-9612973Inferred only
HBB participates in Bacterial Infection PathwaysPathwayReactome R-HSA-9824439Inferred only
HBB participates in Beta globin gene expression regulationPathwayWikiPathways WP5606Inferred only
HBB participates in Binding and Uptake of Ligands by Scavenger ReceptorsPathwayReactome R-HSA-2173782Inferred only

Show the remaining 107

HBB participates in Cellular response to chemical stressPathwayReactome R-HSA-9711123Inferred only
HBB participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
HBB participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
HBB participates in Chaperone Mediated AutophagyPathwayReactome R-HSA-9613829Inferred only
HBB participates in Cytoprotection by HMOX1PathwayReactome R-HSA-9707564Inferred only
HBB participates in DiseasePathwayReactome R-HSA-1643685Inferred only
HBB participates in Effects of nitric oxidePathwayWikiPathways WP1995Inferred only
HBB participates in Erythrocytes take up carbon dioxide and release oxygenPathwayReactome R-HSA-1237044Inferred only
HBB participates in Erythrocytes take up oxygen and release carbon dioxidePathwayReactome R-HSA-1247673Inferred only
HBB participates in ErythropoiesisPathwayWikiPathways WP5607Inferred only
HBB participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only
HBB participates in Folate metabolismPathwayWikiPathways WP176Inferred only
HBB participates in Heme assimilationPathwayReactome R-HSA-9927020Inferred only
HBB participates in Heme signalingPathwayReactome R-HSA-9707616Inferred only
HBB participates in Hemoglobin switching embryonic fetal and adultPathwayWikiPathways WP5605Inferred only
HBB participates in HemostasisPathwayReactome R-HSA-109582Inferred only
HBB participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
HBB participates in Infection with EnterobacteriaPathwayReactome R-HSA-9640148Inferred only
HBB participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
HBB participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
HBB participates in Late endosomal microautophagyPathwayReactome R-HSA-9615710Inferred only
HBB participates in Metal ion assimilation from the hostPathwayReactome R-HSA-9638482Inferred only
HBB participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
HBB participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
HBB participates in O2/CO2 exchange in erythrocytesPathwayReactome R-HSA-1480926Inferred only
HBB participates in Scavenging of heme from plasmaPathwayReactome R-HSA-2168880Inferred only
HBB participates in Selenium micronutrient networkPathwayWikiPathways WP15Inferred only
HBB participates in Sickle cell diseasePathwayWikiPathways WP5604Inferred only
HBB participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
HBB participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
HBB participates in Vitamin B12 metabolismPathwayWikiPathways WP1533Inferred only
HBB regulates positive regulation of nitric oxide biosynthetic processBiological processgene ontology P68871|GO:0045429Inferred only
AKAP11 increases the expression of HBBProteinHetionet hetionet:regulates:11215-3043Inferred only
ALDOA increases the expression of HBBProteinHetionet hetionet:regulates:226-3043Inferred only
ASCL4 increases the expression of HBBProteinHetionet hetionet:regulates:121549-3043Inferred only
ATP5F1D increases the expression of HBBProteinHetionet hetionet:regulates:513-3043Inferred only
CAPNS2 increases the expression of HBBProteinHetionet hetionet:regulates:84290-3043Inferred only
CAV1 increases the expression of HBBProteinHetionet hetionet:regulates:857-3043Inferred only
CBS increases the expression of HBBProteinHetionet hetionet:regulates:875-3043Inferred only
CCNA1 increases the expression of HBBProteinHetionet hetionet:regulates:8900-3043Inferred only
CLK3 increases the expression of HBBProteinHetionet hetionet:regulates:1198-3043Inferred only
CSNK1E increases the expression of HBBProteinHetionet hetionet:regulates:1454-3043Inferred only
DCPS increases the expression of HBBProteinHetionet hetionet:regulates:28960-3043Inferred only
DGKH increases the expression of HBBProteinHetionet hetionet:regulates:160851-3043Inferred only
DYRK3 increases the expression of HBBProteinHetionet hetionet:regulates:8444-3043Inferred only
EBF1 increases the expression of HBBProteinHetionet hetionet:regulates:1879-3043Inferred only
EFCAB14 increases the expression of HBBProteinHetionet hetionet:regulates:9813-3043Inferred only
EIF2AK2 increases the expression of HBBProteinHetionet hetionet:regulates:5610-3043Inferred only
EPAS1 increases the expression of HBBProteinHetionet hetionet:regulates:2034-3043Inferred only
ERAP1 increases the expression of HBBProteinHetionet hetionet:regulates:51752-3043Inferred only
ERCC1 increases the expression of HBBProteinHetionet hetionet:regulates:2067-3043Inferred only
ESR2 increases the expression of HBBProteinHetionet hetionet:regulates:2100-3043Inferred only
ETS2 increases the expression of HBBProteinHetionet hetionet:regulates:2114-3043Inferred only
FANCF increases the expression of HBBProteinHetionet hetionet:regulates:2188-3043Inferred only
FDXR increases the expression of HBBProteinHetionet hetionet:regulates:2232-3043Inferred only
GK5 increases the expression of HBBProteinHetionet hetionet:regulates:256356-3043Inferred only
GMDS increases the expression of HBBProteinHetionet hetionet:regulates:2762-3043Inferred only
GUK1 increases the expression of HBBProteinHetionet hetionet:regulates:2987-3043Inferred only
HLA-DRA increases the expression of HBBProteinHetionet hetionet:regulates:3122-3043Inferred only
HMGB1 increases the expression of HBBProteinHetionet hetionet:regulates:3146-3043Inferred only
HOXB2 increases the expression of HBBProteinHetionet hetionet:regulates:3212-3043Inferred only
HSPA14 increases the expression of HBBProteinHetionet hetionet:regulates:51182-3043Inferred only
HSPA9 increases the expression of HBBProteinHetionet hetionet:regulates:3313-3043Inferred only
IKBKB increases the expression of HBBProteinHetionet hetionet:regulates:3551-3043Inferred only
KMT2A increases the expression of HBBProteinHetionet hetionet:regulates:4297-3043Inferred only
LRRK1 increases the expression of HBBProteinHetionet hetionet:regulates:79705-3043Inferred only
MAP2K4 increases the expression of HBBProteinHetionet hetionet:regulates:6416-3043Inferred only
MAP3K14 increases the expression of HBBProteinHetionet hetionet:regulates:9020-3043Inferred only
MYO3B increases the expression of HBBProteinHetionet hetionet:regulates:140469-3043Inferred only
NDUFA5 increases the expression of HBBProteinHetionet hetionet:regulates:4698-3043Inferred only
NEK7 increases the expression of HBBProteinHetionet hetionet:regulates:140609-3043Inferred only
NMNAT2 increases the expression of HBBProteinHetionet hetionet:regulates:23057-3043Inferred only
NMT1 increases the expression of HBBProteinHetionet hetionet:regulates:4836-3043Inferred only
NUDT6 increases the expression of HBBProteinHetionet hetionet:regulates:11162-3043Inferred only
NUMA1 increases the expression of HBBProteinHetionet hetionet:regulates:4926-3043Inferred only
PANK4 increases the expression of HBBProteinHetionet hetionet:regulates:55229-3043Inferred only
PDHX increases the expression of HBBProteinHetionet hetionet:regulates:8050-3043Inferred only
PIAS2 increases the expression of HBBProteinHetionet hetionet:regulates:9063-3043Inferred only
PIK3R3 increases the expression of HBBProteinHetionet hetionet:regulates:8503-3043Inferred only
PMM2 increases the expression of HBBProteinHetionet hetionet:regulates:5373-3043Inferred only
PNKP increases the expression of HBBProteinHetionet hetionet:regulates:11284-3043Inferred only
POLR2A increases the expression of HBBProteinHetionet hetionet:regulates:5430-3043Inferred only
POLR2E increases the expression of HBBProteinHetionet hetionet:regulates:5434-3043Inferred only
PPIH increases the expression of HBBProteinHetionet hetionet:regulates:10465-3043Inferred only
PSMA1 increases the expression of HBBProteinHetionet hetionet:regulates:5682-3043Inferred only
PSMB2 increases the expression of HBBProteinHetionet hetionet:regulates:5690-3043Inferred only
PSMB5 increases the expression of HBBProteinHetionet hetionet:regulates:5693-3043Inferred only
RAVER1 increases the expression of HBBProteinHetionet hetionet:regulates:125950-3043Inferred only
RBP1 increases the expression of HBBProteinHetionet hetionet:regulates:5947-3043Inferred only
RHOB increases the expression of HBBProteinHetionet hetionet:regulates:388-3043Inferred only
RORC increases the expression of HBBProteinHetionet hetionet:regulates:6097-3043Inferred only
RPN2 increases the expression of HBBProteinHetionet hetionet:regulates:6185-3043Inferred only
RXRA increases the expression of HBBProteinHetionet hetionet:regulates:6256-3043Inferred only
RXRG increases the expression of HBBProteinHetionet hetionet:regulates:6258-3043Inferred only
RYK increases the expression of HBBProteinHetionet hetionet:regulates:6259-3043Inferred only
SDHD increases the expression of HBBProteinHetionet hetionet:regulates:6392-3043Inferred only
SLC16A2 increases the expression of HBBProteinHetionet hetionet:regulates:6567-3043Inferred only
SOD1 increases the expression of HBBProteinHetionet hetionet:regulates:6647-3043Inferred only
SP100 increases the expression of HBBProteinHetionet hetionet:regulates:6672-3043Inferred only
SRM increases the expression of HBBProteinHetionet hetionet:regulates:6723-3043Inferred only
SUPT4H1 increases the expression of HBBProteinHetionet hetionet:regulates:6827-3043Inferred only
TAOK3 increases the expression of HBBProteinHetionet hetionet:regulates:51347-3043Inferred only
TFCP2 increases the expression of HBBProteinHetionet hetionet:regulates:7024-3043Inferred only
TIMP1 increases the expression of HBBProteinHetionet hetionet:regulates:7076-3043Inferred only
TNFSF4 increases the expression of HBBProteinHetionet hetionet:regulates:7292-3043Inferred only
WARS2 increases the expression of HBBProteinHetionet hetionet:regulates:10352-3043Inferred only
ZBTB49 increases the expression of HBBProteinHetionet hetionet:regulates:166793-3043Inferred only

Other names

3 names

Resolves to: HBB

Also called: [Cleaved into: LVV-hemorphin-7; Spinorphin]Beta-globinHemoglobin beta chain

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