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Proteins/UNIPROT:Q8TCG2
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking..
Function from UniProtKB (Q8TCG2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
187 statements
187 statements · 6 reference databases · Subject: PI4K2B · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
ATP+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ADP+proton
Catalysed by PI4K2B or PI4KB or PI4K2A or PI4KA
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.67cytosol
Human-GEM MAR06546CC BY 4.0Reference data
ATP+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)
2 names
Resolves to: PI4K2B
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.67nucleus
Human-GEM MAR08830CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+ATP(4-)a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ADP(3-)+hydron
Catalysed by PI4KA or PI4K2B or PI4K2A or PI4KB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19877CC BY 4.0Reference data