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Proteins/UNIPROT:Q5SY16
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates. Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus..
Function from UniProtKB (Q5SY16), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
34 statements
34 statements · 3 reference databases · Subject: NOL9 · Sources: Hetionet, Reactome, WikiPathways
2 reactions
a 5'-end dephospho-2'-deoxyribonucleoside-DNA+ATP(4-)a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA+ADP(3-)+hydron
Catalysed by NOL9 or CLP1 or PNKP
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15669CC BY 4.0Reference data
a 5'-end dephospho-ribonucleoside-RNA+ATP(4-)a 5'-end 5'-phospho-ribonucleoside-RNA+ADP(3-)+hydron
Catalysed by
1 name
Resolves to: NOL9
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:54580CC BY 4.0Reference data