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Proteins/UNIPROT:O00257
E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate. Also acts as a histone reader, which specifically recognizes and binds histone H3 trimethylated at 'Lys-9' and 'Lys-27' (H3K9me3 and H3K27me3, respectively) via its chromo domain (By similarity). Catalyzes sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Acts as a regulator of brown adipocyte differentiation by mediating sumoylation of PRDM16, thereby preventing PRDM16 ubiquitination and degradation (By similarity). Monosumoylates ZBTB35. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity)..
(Microbial infection) Plays a critical for EV71 infection through SUMOylation E3 ligase function. Enhances the stability of EV71 RNA-directed RNA polymerase by regulating its SUMOylation and 'Lys-63'-linked ubiquitination..
Function from UniProtKB (O00257), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
144 statements
144 statements · 3 reference databases · Subject: CBX4 · Sources: gene ontology, Hetionet, Reactome
4 names
Resolves to: CBX4