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Proteins/UNIPROT:O15105
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator..
Function from UniProtKB (O15105), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
332 statements
332 statements · 4 reference databases · Subject: SMAD7 · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
10 names
Resolves to: SMAD7