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Proteins/UNIPROT:P78356
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3..
Function from UniProtKB (P78356), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
79 statements
79 statements · 6 reference databases · Subject: PIP4K2B · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
ATP+MAM02735rADP+proton+MAM02734r
Catalysed by PIP4K2A or PIP4K2C or PIP4K2B
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68endoplasmic reticulum
Human-GEM MAR03004CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+ATPADP+proton+MAM02735r
Catalysed by
7 names
Resolves to: PIP4K2B
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68endoplasmic reticulum
Human-GEM MAR03325CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ATPADP+proton+MAM02736c
Catalysed by PIP4K2A or PIP4K2C or PIP4K2B
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.149cytosol
Human-GEM MAR06554CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ATPADP+proton+MAM02736n
Catalysed by PIP4K2A or PIP4K2C or PIP4K2B
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.149nucleus
Human-GEM MAR08826CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ATP(4-)a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+ADP(3-)+hydron
Catalysed by PIP4K2A or PIP4K2B or PIP4K2C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12280CC BY 4.0Reference data
CHEBI:84968+GTPCHEBI:83423+GDP+hydron
Catalysed by PIP4K2A or PIP4K2B or PIP4K2C
Reaction pageLeft to rightBalanced
Rhea RHEA:55964CC BY 4.0Reference data
CHEBI:84968+ATP(4-)CHEBI:83423+ADP(3-)+hydron
Catalysed by PIP4K2A or PIP4K2B or PIP4K2C
Reaction pageLeft to rightBalanced
Rhea RHEA:55992CC BY 4.0Reference data