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Proteins/UNIPROT:P99999
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Function from UniProtKB (P99999), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
523 statements
523 statements · 3 reference databases · Subject: CYCS · Sources: Hetionet, Reactome, WikiPathways · Rows fetched: 300
2 names
Resolves to: CYCS