Pathway
Arachidonate production from DAG
Diacylglycerol (DAG) is an important source of arachidonic acid, a signalling molecule and the precursor of the prostaglandins. In human platelet almost all the DAG produced from phosphatidylinositol degradation contains arachidonate. DAG is hydrolysed by DAG lipase to 2-arachidonylglycerol (2-AG) which is further hydrolysed by monoacylglycerol lipase. 2-AG is an agonist of cannabinoid receptor 1.
REACT:R-HSA-426048Reactome
What the reference databases state
Statements
5 statements
5 statements · 1 reference database · Subject: Arachidonate production from DAG · Sources: Reactome
- ABHD12 participates in Arachidonate production from DAGProteinReactome R-HSA-426048Inferred only
- ABHD6 participates in Arachidonate production from DAGProteinReactome R-HSA-426048Inferred only
- DAGLA participates in Arachidonate production from DAGProteinReactome R-HSA-426048Inferred only
- DAGLB participates in Arachidonate production from DAGProteinReactome R-HSA-426048Inferred only
- MGLL participates in Arachidonate production from DAGProteinReactome R-HSA-426048Inferred only