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Proteins/UNIPROT:O75962
Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth. Plays a key role in the regulation of neurite outgrowth and lamellipodia formation. In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity)..
Function from UniProtKB (O75962), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
101 statements
101 statements · 4 reference databases · Subject: TRIO · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 reactions
1 name
Resolves to: TRIO
Rhea RHEA:17989CC BY 4.0Reference data