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Proteins/UNIPROT:Q9NR28
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases..
[Isoform 3]: Attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation..
[Isoform 1]: Defective in the capacity to down-regulate the XIAP/BIRC4 abundance..
Function from UniProtKB (Q9NR28), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
192 statements
192 statements · 4 reference databases · Subject: DIABLO · Sources: gene ontology, Hetionet, Reactome, WikiPathways
5 names
Resolves to: DIABLO