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Proteins/UNIPROT:O43766
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives..
Function from UniProtKB (O43766), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
65 statements
65 statements · 6 reference databases · Subject: LIAS · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
MAM00210m+3proton+NADPH(4-)+2S-adenosyl-L-methionine+tetra-mu3-sulfido-tetrairon(2+)MAM00208m+2MAM01098m+4iron(2+)+2hydrogen sulfide+2L-methionine+NADP(3-)
5 names
Resolves to: LIAS
Reaction pageLeft to rightBalancedEC 2.8.1.8mitochondrial matrix
Human-GEM MAR06403CC BY 4.0Reference data
[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster]+N(6)-octanoyl-L-lysyl-[protein]+2oxidized [2Fe-2S]-[ferredoxin]+2S-adenosyl-L-methionine+4hydron[[Fe-S] cluster scaffold protein]+N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein]+4Fe(3+)+2hydrogen sulfide+25'-deoxyadenosine+2L-methionine+2reduced [2Fe-2S]-[ferredoxin]
Catalysed by LIAS
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:16585CC BY 4.0Reference data