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Proteins/UNIPROT:Q16769
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides..
Function from UniProtKB (Q16769), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
78 statements
78 statements · 2 reference databases · Subject: QPCT · Sources: Hetionet, Reactome
2 reactions
MAM02375cMAM01128c+ammonium
Catalysed by QPCT
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.5cytosol
Human-GEM MAR09543CC BY 4.0Reference data
N-terminal L-glutaminyl-[peptide]N-terminal 5-oxo-L-prolyl-[peptide]+ammonium
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:23652CC BY 4.0Reference data
6 names
Resolves to: QPCT