TRAF1

Adapter molecule that is involved in multiple signaling pathways including the NF-kappa-B and MAPK pathways and thus influences inflammatory and apoptotic responses. Plays a critical role in regulating T-cell activation both through restricting the costimulation-independent activation of NIK in activated T-cells and by promoting the TNFRSF9-induced classical NF-kappa-B pathway (By similarity). Forms a heterotrimer with TRAF2 as part of an E3 ubiquitin-protein ligase complex that mediates ubiquitination of target proteins such as MAP3K14 and gasdermin D/GSDMD. This complex also recruits the antiapoptotic E3 ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Acts downstream of MAVS within the RIG-I/MAVS antiviral pathway to enhance type I interferon signaling. Regulates osteoclastogenesis by preventing ubiquitination and degradation of MLST8, thereby promoting PI3K-AKT signaling and enhancing oxidative phosphorylation in osteoclasts (By similarity)..

Function from UniProtKB (Q13077), read 2026-09-23. CC BY 4.0.