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Proteins/UNIPROT:P50213
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers..
Function from UniProtKB (P50213), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
171 statements
171 statements · 8 reference databases · Subject: IDH3A · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
isocitric acid+NAD(+)2-oxoglutarate(2-)+carbon dioxide+NADH(2-)
Catalysed by IDH3B & IDH3A & IDH3G
Reaction pageLeft to rightBalancedEC 1.1.1.41mitochondrial matrix
Human-GEM MAR03957CC BY 4.0Reference data
D-threo-isocitrate+NAD(1-)2-oxoglutarate(2-)+carbon dioxide+
2 names
Resolves to: IDH3A
Catalysed by IDH3A
Reaction pageLeft to rightBalanced
Rhea RHEA:23632CC BY 4.0Reference data