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Proteins/UNIPROT:Q99808
Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter. Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine. Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Also mediates the uptake of nicotinamide; contributes to maintaining nicotinamide homeostasis but also regulated nicotinamide biological roles. Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure..
Function from UniProtKB (Q99808), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
133 statements
133 statements · 6 reference databases · Subject: SLC29A1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
32 reactions
2'-deoxyguanosine2'-deoxyguanosine
Transported by SLC29A1 or SLC29A2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR04997CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05003CC BY 4.0Reference data
7 names
Resolves to: SLC29A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05008CC BY 4.0Reference data
Transported by SLC29A1
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR05031CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A4 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05032CC BY 4.0Reference data
Transported by SLC29A1
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR05033CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05034CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05035CC BY 4.0Reference data
Transported by SLC29A1
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol
Human-GEM MAR05036CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05037CC BY 4.0Reference data
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05042CC BY 4.0Reference data
2'-deoxyguanosine2'-deoxyguanosine
Transported by SLC29A1 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06366CC BY 4.0Reference data