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Proteins/UNIPROT:P19388
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template..
Function from UniProtKB (P19388), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
321 statements
321 statements · 3 reference databases · Subject: POLR2E · Sources: Hetionet, Reactome, WikiPathways · Rows fetched: 300
2 reactions
5 names
Resolves to: POLR2E
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.6, 2.7.7.19, 2.7.7.52nucleus
Human-GEM MAR07161CC BY 4.0Reference data
phosphate(3-)+MAM02847c0.18ADP+0.3CHEBI:17239+0.34GDP+0.18UDP
Catalysed by POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & MTPAP & POLR3B & POLR1H & POLR3K & POLR3H or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & PAPOLA & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & PAPOLG & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & PAPOLG & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & PAPOLG & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & TENT2 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & TENT2 & POLR3C & POLR1E & POLR3F & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TENT2 & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT7 & POLR3C & POLR1E & POLR3F & POLR1B & PAPOLB & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & TUT4 & POLR3C & POLR1E & POLR3F & POLR1B & PAPOLB & POLR3E & or POLRMT & POLR3A & POLR1C & POLR3G & POLR2D & POLR1A & POLR3D & POLR1D & POLR2C & POLR2E & POLR2B & POLR2I & POLR2H & POLR2J & POLR2K & POLR2F & POLR2G & POLR2L & POLR3C & POLR1E & POLR3F & TUT1 & POLR1B & PAPOLB & POLR3E & and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.8cytosol
Human-GEM MAR07162CC BY 4.0Reference data