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Proteins/UNIPROT:Q7LGA3
Catalyzes the transfer of a sulfo group from 3'-phospho-5'-adenylyl sulfate (PAPS) to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within the heparan sulfate (HS) chain and participates in HS biosynthesis (By similarity). Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme (By similarity)..
Function from UniProtKB (Q7LGA3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
236 statements
236 statements · 4 reference databases · Subject: HS2ST1 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
3 reactions
7 names
Resolves to: HS2ST1
3,3'-diiodo-L-thyronine+3'-phospho-5'-adenylyl sulfate3,3'-diiodo-L-thyronine sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by NDST1 or UST or CHST10 or SULT4A1 or CHST7 or HS2ST1 or CHST9 or GAL3ST2 or NDST3 or SULT1B1 or HS6ST3 or GAL3ST4 and 2 more alternatives
Reaction pageLeft to rightBalancedEC 2.8.2.-cytosol
Human-GEM MAR06829CC BY 4.0Reference data
MAM02083g+23'-phospho-5'-adenylyl sulfate2proton+MAM02084g+2adenosine 3',5'-bismonophosphate
Catalysed by HS2ST1
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07218CC BY 4.0Reference data