2-iminobutanoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

85 compounds within 3 steps: 1 in 1, 12 in 2, 72 in 3

Three steps

formic acidReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-hydroxybutyrate:NAD+ oxidoreductase
3. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)
Catalysed by RIDA, LDHB, LDHC, LDHAL6A and 5 morecytosol, extracellular spaceOne of 4 routes
propionic acidReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-hydroxybutyrate:NAD+ oxidoreductase
3. transport of 2-hydroxybutyrate and propanoate (cytosol to extracellular)
Catalysed by RIDA, LDHB, LDHC, LDHAL6A and 5 morecytosol, extracellular spaceOne of 7 routes
butyric acidReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-hydroxybutyrate:NAD+ oxidoreductase
3. transport of 2-hydroxybutyrate and butyrate (cytosol to extracellular)
Catalysed by RIDA, LDHB, LDHC, LDHAL6A and 5 morecytosol, extracellular spaceOne of 4 routes
3-hydroxypyruvic acidReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. L-Serine:pyruvate aminotransferase
Catalysed by RIDA, AGXT2, AGXTcytosolOne of 2 routes
glutarateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O
3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
Catalysed by RIDA, AADAT, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes
3-oxopropanoateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
Catalysed by RIDA, AGXT2
2-oxohexanoateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
Catalysed by RIDA, AGXT2
D-serineReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. D-serine = pyruvate + NH4(+)
Catalysed by RIDA, AGXT2, SRR
3-(4-hydroxyphenyl)pyruvateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
Catalysed by RIDA, AGXT2, AADAT
(R)-lactic acidReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. (R)-Lactate:NAD+ oxidoreductase
Catalysed by RIDA, AGXT2, LDHDcytosol
(S)-lactic acidReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-hydroxybutyrate:NAD+ oxidoreductase
3. transport of 2-hydroxybutyrate and L-lactate (cytosol to extracellular)
Catalysed by RIDA, LDHB, LDHC, LDHAL6A and 8 morecytosol, extracellular spaceOne of 7 routes
2-iminopropanoateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. 2-iminopropanoate + H2O = pyruvate + NH4(+)
Catalysed by RIDA, AGXT2
phosphoenolpyruvic acidReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. pyruvate kinase (dTDP)
Catalysed by RIDA, AGXT2, PKM, PKLRcytosol
N-acetyl-beta-neuraminic acidReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by RIDA, AGXT2, NPLcytosol
a 3-acylpyruvateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
Catalysed by RIDA, AGXT2, FAHD1
glycineReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. L-threonine = 2-oxobutanoate + NH4(+)
3. L-threonine = acetaldehyde + glycine
Catalysed by RIDA, SDS, SDSL, SHMT1One of 17 routes
(S)-methylmalonyl-CoAReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutyrate oxidation
3. propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
Catalysed by RIDA, PCCA, PCCBcytosol, mitochondrial matrix
acryloyl-CoAReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutyrate oxidation
3. medium-chain acyl-CoA dehydrogenase (propanoyl-CoA)
Catalysed by RIDA, ACADS, ACADSBcytosol, mitochondrial matrix
2-oxoadipateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
Catalysed by RIDA, AGXT2, AADAT
2-oxo-3-sulfanylpropanoateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
Catalysed by RIDA, AGXT2, MPST
2-methyl-3-oxopropanoateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
Catalysed by RIDA, AGXT2
L-methionineReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
Catalysed by RIDA, AGXT2, TYW1B, TYW1
L-alanineReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. L-threonine = 2-oxobutanoate + NH4(+)
3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
Catalysed by RIDA, SDS, SDSL, SLC7A10inner side of the membrane, outer side of the membraneOne of 23 routes
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O
3. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
Catalysed by RIDA, AADAT, AGXT2One of 7 routes
trans-4-hydroxy-L-prolineReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. L-threonine = 2-oxobutanoate + NH4(+)
3. trans-4-hydroxy-L-proline(out) + L-threonine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-threonine(out) + Na(+)(in)
Catalysed by RIDA, SDS, SDSL, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes
(3S)-citramalyl-CoAReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by RIDA, AGXT2, CLYBL
5-amino-2-oxopentanoateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
Catalysed by RIDA, AGXT2One of 2 routes
(4R)-4-hydroxy-2-oxoglutarateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by RIDA, AGXT2, HOGA1One of 2 routes
xanthurenateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
Catalysed by RIDA, AGXT2, KYAT3, AADAT
(4S)-4-hydroxy-2-oxoglutarateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by RIDA, AGXT2, HOGA1One of 2 routes
L-threonylcarbamoyladenylateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. L-threonine = 2-oxobutanoate + NH4(+)
3. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
Catalysed by RIDA, SDS, SDSL, YRDC
3-methylmalateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
Catalysed by RIDA, AGXT2, CLYBL
Se-methylselenocysteineReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. Selenocystathionine Lysteine-lyase (deaminating)
3. L-Serine hydro-lyase (adding homocysteine)
Catalysed by RIDA, CTH, CBScytosol
thiamine(1+) diphosphateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)
3. lipoamide to thiamin-PP conversion
Catalysed by RIDA, BCKDHA, BCKDHB, DBTmitochondrial matrix
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by RIDA, AGXT2, PDHA1, PDHB and 1 moremitochondrial matrix