1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

Three steps

• L-valineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by PLD2, PLD1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• oxaloacetateReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by PLD2, PLD1, CHAT, ACLYcytosol

• L-arginineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by PLD2, PLD1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• nitric oxideReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O

  Catalysed by PLD2, PLD1, CHDH, SUOX

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by PLD2, PLD1, CHDH, RSAD2

• (S)-2-hydroxyglutarateReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by PLD2, PLD1, CHDH, L2HGDH

• CHEBI:16856Reach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by PLD2, PLD1, CHAT, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:16857Reach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by PLD2, PLD1, SLC5A7, SLC6A14extracellular space, cytosol

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)
  2. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  3. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase

  Catalysed by PLB1, GPCPD1, GPAT3, GPAT2 and 2 morecytosol, mitochondrial matrixOne of 9 routes

• oxalic acidReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by PLD2, PLD1, SLC5A7, SLC26A6extracellular space, cytosol

• a cholesterol esterReach from here →
  1. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by TAFAZZIN, LCATendoplasmic reticulumOne of 3 routes

• L-isoleucineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by PLD2, PLD1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• CHEBI:17203Reach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by PLD2, PLD1, SLC5A7, CLTRN and 1 moreextracellular space, cytosolOne of 2 routes

• anilineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by PLD2, PLD1, CHAT, NAT2 and 1 morecytosol

• CHEBI:17312Reach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by PLD2, PLD1, CHATcytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by PLD2, PLD1, CHDH, CDK5RAP1One of 4 routes

• linoleic acidReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  2. SM pool hydrolysis
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SGMS2cytosol, extracellular spaceOne of 14 routes

• D-glyceraldehydeReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  3. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)

  Catalysed by PLB1, ENPP6, AKR1A1, AKR1B1

• a monoacylglycerolReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  3. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

  Catalysed by PLB1, ENPP6, LIPE

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA

  Catalysed by PLAAT3, PLA2G15, PLAAT1, PLAAT2 and 15 more

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
  2. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  3. Lecithin Retinol Acyltransferase

  Catalysed by LRAT, PNLIP, PNPLA4, LIPEcytosolOne of 2 routes

• L-cysteineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PLD2, PLD1, CHAT, NAGScytosol, mitochondrial matrixOne of 3 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by PLD2, PLD1, CHDH, DIO1

• 3,3'-diiodo-L-thyronineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by PLD2, PLD1, CHDH, DIO1 and 1 moreOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by PLD2, PLD1, CHDH, DIO1One of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by PLD2, PLD1, CHAT, HADHA and 2 morecytosol, mitochondrial matrix

• glycine betaineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline dehydrogenase (choline)
  3. p-cumic alcohol:NAD+ oxidoreductase

  Catalysed by PLD2, PLD1, CHDH, ALDH7A1cytosolOne of 7 routes

• a 1,2-diacyl-sn-glycerolReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. ceramide:phosphatidylcholine cholinephosphotransferase

  Catalysed by SGMS2, SGMS1endoplasmic reticulum, Golgi apparatusOne of 12 routes

• a triacylglycerolReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a triacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS2, SGMS1, TMEM68

• CHEBI:17895Reach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by PLD2, PLD1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• all-trans-retinalReach from here →
  1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
  2. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  3. retinol: NADP+ oxidoreductase

  Catalysed by LRAT, PNLIP, PNPLA4, LIPE and 6 morecytosolOne of 6 routes

• CHEBI:17927Reach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PLD2, PLD1, CHATcytosol

• CHEBI:18019Reach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by PLD2, PLD1, SLC5A7, SLC6A14extracellular space, cytosol

• a diacylglycerolReach from here →
  1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
  2. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  3. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol

  Catalysed by LRAT, PNLIP, PNPLA4, LIPE and 1 more

• L-glutamineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by PLD2, PLD1, SLC5A7, SLC6A14extracellular space, cytosol

• CHEBI:18095Reach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by PLD2, PLD1, SLC5A7, CLTRN and 1 moreextracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by PLD2, PLD1, SLC5A7extracellular space, cytosolOne of 2 routes

• dodecanoateReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  2. SM pool hydrolysis
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SGMS2cytosol, extracellular spaceOne of 12 routes

• D-glucosyl-N-acylsphingosineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. UDP-glucose:N-acylsphingosine D-glucosyltransferase

  Catalysed by SGMS2, UGCGendoplasmic reticulum, cytosolOne of 2 routes

• a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by SGMS2, UGT8endoplasmic reticulumOne of 2 routes

• a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

  Catalysed by SGMS2, GBA1, GBA3endoplasmic reticulumOne of 2 routes

• 11-cis-retinyl esterReach from here →
  1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
  2. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by LRAT, RPE65, AWAT2

• 3',5'-diiodo-L-thyronineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by PLD2, PLD1, CHDH, DIO3

• a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by SGMS2, UGCGendoplasmic reticulumOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by PLD2, PLD1, CHAT, HADHA and 2 morecytosol, mitochondrial matrixOne of 2 routes

• 3-iodothyronamineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by PLD2, PLD1, CHDH, DIO1 and 1 moreOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by PLD2, PLD1, CHAT, SLC27A2 and 7 morecytosolOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by PLD2, PLD1, CHDH, DIO1 and 1 moreOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by PLD2, PLD1, CHAT, SLC27A2 and 7 morecytosolOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by PLD2, PLD1, CHDH, DIO1 and 1 moreOne of 2 routes