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Proteins/UNIPROT:Q9NWW9
Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity..
Function from UniProtKB (Q9NWW9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
39 statements
39 statements · 4 reference databases · Subject: PLAAT2 · Sources: Hetionet, Human-GEM, Reactome, Rhea
25 reactions
CHEBI:1146900+proton+MAM02538cCHEBI:15351+CHEBI:15650
Catalysed by LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or ZDHHC15 or ZDHHC2 or NAT9 or NAA40 or LPCAT3 or NAA60 or MBOAT7 and 20 more alternatives
2 names
Resolves to: PLAAT2
Human-GEM MAR01088CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
Reaction pageReversibleBalancedEC 2.3.1.-nucleus
Human-GEM MAR01091CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:15801CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 2-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by LPL or LIPC or PLAAT3 or PLA2G15 or DDHD1 or ABHD3 or PLAAT5 or PLAAT1 or PNPLA8 or PLAAT2 or PLAAT4 or LIPG
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18689CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(9Z)-octadecenoate+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PLA2G5 or PLAAT3 or PLB1 or PLA2G4D or PLA2G15 or PLA2G2F or PNPLA8 or PLAAT2 and 4 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:38779CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by DDHD2 or PLAAT3 or PLA2G4F or PLA2G15 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:38783CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by PLA2G6 or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT1 or PNPLA8 or PLAAT2 or PLA2G3 and 1 more alternative
Reaction pageLeft to rightBalanced
Rhea RHEA:40431CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+water2-hexadecanoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by PLAAT3 or PLA2G15 or PLAAT1 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:40487CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by PLA2G4B or PLAAT3 or PNPLA8 or PLAAT2 or PLAAT4 or PLA2G4C
Reaction pageLeft to rightBalanced
Rhea RHEA:40571CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(9Z,12Z)-octadecadienoate+hydron
Catalysed by PLA2G10 or PLA2G1B or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT2 or PLA2G3 or PLA2G2E and 2 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:40815CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PRDX6 or PLAAT3 or PLB1 or PLA2G15 or PLAAT1 or PLAAT2 or PLA2G2E or PLAAT4 and 2 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:41223CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+water2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine+hexadecanoate+hydron
Catalysed by PLAAT3 or PLAAT1 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:41348CC BY 4.0Reference data