Loading the page.
Proteins/UNIPROT:P53816
Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity. Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity)..
(Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm. May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection. Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome. May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery. The lipid-modifying enzyme activity is required for this process..
Function from UniProtKB (P53816), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
120 statements
120 statements · 7 reference databases · Subject: PLAAT3 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
34 reactions
14 names
Resolves to: PLAAT3
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4endoplasmic reticulum
Human-GEM MAR00463CC BY 4.0Reference data
water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR00630CC BY 4.0Reference data
water+phosphatidylethanolamineMAM00511c+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR00643CC BY 4.0Reference data
water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4lysosome
Human-GEM MAR05254CC BY 4.0Reference data
water+1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR07603CC BY 4.0Reference data
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+waterMAM00549c+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR07615CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:15801CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 2-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by LPL or LIPC or PLAAT3 or PLA2G15 or DDHD1 or ABHD3 or PLAAT5 or PLAAT1 or PNPLA8 or PLAAT2 or PLAAT4 or LIPG
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18689CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(9Z)-octadecenoate+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PLA2G5 or PLAAT3 or PLB1 or PLA2G4D or PLA2G15 or PLA2G2F or PNPLA8 or PLAAT2 and 4 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:38779CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by DDHD2 or PLAAT3 or PLA2G4F or PLA2G15 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:38783CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by PLA2G6 or PLA2G1B or LCAT or PLA2G4B or PLA2G5 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F or PLA2G4D or PNPLA8 or PLA2G3 and 1 more alternative
Reaction pageLeft to rightBalanced
Rhea RHEA:40427CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by PLA2G6 or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT1 or PNPLA8 or PLAAT2 or PLA2G3 and 1 more alternative
Reaction pageLeft to rightBalanced
Rhea RHEA:40431CC BY 4.0Reference data