L-tyrosine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

515 compounds within 3 steps: 8 in 1, 108 in 2, 399 in 3

Three steps

2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. transport of glutamine and phenylalanine (cytosol to extracellular)
3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)
Catalysed by PAH, SLC7A5, PFASextracellular space, cytosol
gamma-L-glutamyl-(2S)-2-aminobutanoateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. (2S)-2-aminobutanoate + L-glutamate + ATP = gamma-L-glutamyl-(2S)-2-aminobutanoate + ADP + phosphate + H(+)
Catalysed by AADAT, AGXT2, GCLC
2-aminoisobutanoateReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. transport of alanine and phenylalanine (cytosol to extracellular)
3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)
Catalysed by PAH, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione
Catalysed by AADAT, GSS, MGST3
3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)
Catalysed by PAH, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes
L-sepiapterinReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
Catalysed by PAH, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes
(6R)-10-formyltetrahydrofolateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate
Catalysed by AADAT, SHMT1, SHMT2, MTHFD1 and 1 more
(5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by AADAT, GSS, GPX1, GPX4
(12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by AADAT, GSS, GPX1, GPX4
(15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O
Catalysed by AADAT, GSS, GPX1, GPX4
(17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O
Catalysed by AADAT, GSS, GPX1, GPX4
a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O
Catalysed by AADAT, GSS, GPX4
glycodeoxycholate 3-sulfateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. Glycodeoxycholate amidohydrolase
3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by AADAT, SULT2A1cytosol
5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by TAT, AADAT, AGXT2One of 8 routes
5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by TAT, AADAT, AGXT2One of 3 routes
5-(3-methylguanidino)-2-oxopentanoateReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
Catalysed by TAT, AADAT, AGXT2One of 3 routes
(6R)-5,10-methylenetetrahydrofolic acidReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
Catalysed by AADAT, SHMT1cytosolOne of 7 routes
S-disulfanyl-L-cysteineReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. transport of cysteine and phenylalanine (cytosol to extracellular)
3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine
Catalysed by PAH, SLC7A5, CARS2extracellular space, cytosol
(5Z)-dodecenoyl-CoAReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)
Catalysed by AADAT, BAAT, HADHA, ACAA2 and 1 moreperoxisome, mitochondrial matrixOne of 2 routes
(11Z)-docosenoyl-CoA(4-)Reach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)
Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes
(7Z)-tetradecenoyl-CoAReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)
Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 8 routes
(4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
Catalysed by AADAT, BAAT, HADHA, ACADVL and 1 moreperoxisome, mitochondrial matrixOne of 3 routes
(7Z,10Z)-hexadecadienoyl-CoAReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
Catalysed by AADAT, BAAT, HADHA, ACADVL and 1 moreperoxisome, mitochondrial matrix
(4Z,7Z)-decadienoyl-CoAReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
Catalysed by AADAT, BAAT, ECHS1, ACAA2 and 1 moreperoxisome, mitochondrial matrixOne of 2 routes
(5Z)-octenoyl-CoAReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial
Catalysed by AADAT, BAAT, ECHS1, ACAA2 and 1 moreperoxisome, mitochondrial matrixOne of 2 routes
3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal
Catalysed by AADAT, GSS, GSTP1
glycoursodeoxycholate 3-sulfateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glycine to glycoursodeoxycholate conversion
3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by AADAT, SULT2A1cytosol
glycochenodeoxycholate 3-sulfateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by AADAT, BAAT, SULT2A1
deoxycholateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. Glycodeoxycholate amidohydrolase
3. Glycodeoxycholate amidohydrolase
Catalysed by AADATcytosol
a quinolReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
Catalysed by AADAT, GSS, SQOR
hypochlorous acidReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. Transport of L-Phenylalanine by Atb0 Transporter
3. Peroxidase
Catalysed by PAH, SLC6A14, LPOextracellular space, cytosolOne of 4 routes
folic acidReach from here →
1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
3. Folate Transport by Oats
Catalysed by SLC7A13, SLC25A14, SLC25A30, SLC22A8 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
CHEBI:27540Reach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. medium-chain acyl-CoA ligase (hexanoic acid)
Catalysed by AADAT, BAAT, ACSM4, ACSM1 and 4 moreperoxisome, cytosolOne of 6 routes
3,4-dihydroxyphenylacetaldehydeReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
2. L-dopa + H(+) = dopamine + CO2
3. monoamine oxidase (dopamine)
Catalysed by TH, DDC, AOC2, AOC1 and 3 morecytosolOne of 2 routes
elaidic acidReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (elaidate)
Catalysed by AADAT, BAAT, SLC27A2, ACSL4 and 6 moreperoxisome, cytosolOne of 5 routes
5-hydroxytryptophanReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)
Catalysed by TH, TPH1, TPH2cytosolOne of 2 routes
5(S)-HETEReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. Glutathione: 5-HPETE oxidoreductase
Catalysed by AADAT, GSS, GPX5, GPX1 and 7 morecytosolOne of 2 routes
(2-hydroxyphenyl)acetic acidReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. Phenylalanine Transaminase, Mitochondrial
3. Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)
Catalysed by PAH, GOT2, TAT, HPDmitochondrial matrix, cytosol
CHEBI:28701Reach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. bile acid-CoA: amino acid N-acyltransferase
3. Propanoyl-CoA:acetyl-CoA C-acyltransferase
Catalysed by AADAT, BAAT, ACAA1, SCP2 and 1 moreperoxisomeOne of 7 routes
pyridoxine 5'-phosphateReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. transport of alanine and phenylalanine (cytosol to extracellular)
3. L-selenocysteine selenide-lyase (L-alanine-forming)
Catalysed by PAH, SLC7A5, SCLYextracellular space, cytosol
3-disulfanyl-L-alanineReach from here →
1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
2. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
3. L-cystine thiocysteine-lyase (deaminating
Catalysed by SLC7A13, CTHinner side of the membrane, outer side of the membrane, cytosol
N-acetyl-L-cysteineReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. transport of cysteine and phenylalanine (cytosol to extracellular)
3. N-acetylglutamate synthase (N-acetyl-L-cysteine)
Catalysed by PAH, SLC7A5, NAGSextracellular space, cytosol, mitochondrial matrix
L-ascorbic acidReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
Catalysed by AADAT, GSS, CLIC1, GSTO1 and 1 more
Ca(2+)Reach from here →
1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
2. transport of aspartate (cytosol to extracellular)
3. transport of Ca2+ and K+ (cytosol to extracellular)
Catalysed by SLC7A13, SLC1A7, SLC1A3, SLC1A2 and 7 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes
Cys-tRNA(Cys)Reach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. transport of cysteine and phenylalanine (cytosol to extracellular)
3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)
Catalysed by PAH, SLC7A5, CARS1extracellular space, cytosol
Trp-tRNA(Trp)Reach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)
Catalysed by TH, TPH1, TPH2, WARS1cytosol
Ile-tRNA(Ile)Reach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. transport of isoleucine and phenylalanine (cytosol to extracellular)
3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)
Catalysed by PAH, SLC7A5, IARS1extracellular space, cytosol
Gln-tRNA(Gln)Reach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. transport of glutamine and phenylalanine (cytosol to extracellular)
3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)
Catalysed by PAH, SLC7A5, QARS1extracellular space, cytosol
isocyanateReach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. transport of citrulline and phenylalanine (cytosol to extracellular)
3. L-citrulline + H(+) = isocyanate + L-ornithine
Catalysed by PAH, SLC7A6, LACC1extracellular space, cytosol
Asn-tRNA(Asn)Reach from here →
1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
2. transport of asparagine and phenylalanine (cytosol to extracellular)
3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)
Catalysed by PAH, SLC7A5, NARS1extracellular space, cytosol