L-tyrosine

Two steps

• L-isoleucineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of isoleucine and phenylalanine (cytosol to extracellular)

  Catalysed by PAH, SLC7A5extracellular space, cytosolOne of 9 routes

• CHEBI:17203Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of phenylalanine and proline (cytosol to extracellular)

  Catalysed by PAH, SLC7A5extracellular space, cytosolOne of 6 routes

• (S)-4-hydroxymandelateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. 3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2

  Catalysed by TAT, HPDL

• 5-aminolevulinic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by AADAT, ALAS1, ALAS2, CPNE7mitochondrial matrix

• L-cysteineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by PAH, SLC7A5extracellular space, cytosolOne of 10 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by PAH, TPH1, TPH2

• CHEBI:17895Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of phenylalanine and tyrosine (cytosol to extracellular)

  Catalysed by PAH, SLC7A5extracellular space, cytosolOne of 9 routes

• 3-phenylpyruvateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. Phenylalanine Transaminase, Mitochondrial

  Catalysed by PAH, GOT2, TATmitochondrial matrixOne of 5 routes

• CHEBI:18019Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of lysine and phenylalanine (cytosol to extracellular)

  Catalysed by PAH, SLC7A6extracellular space, cytosolOne of 4 routes

• L-glutamineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of glutamine and phenylalanine (cytosol to extracellular)

  Catalysed by PAH, SLC7A5extracellular space, cytosolOne of 13 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by AADAT, GARTcytosol

• 2-phenylethylamineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by PAH, DDCcytosol

• ophthalmateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by AADAT, GSS

• S-methylmercury-L-cysteineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

  Catalysed by PAH, SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AADAT, AGXT2

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by AADAT, SHMT1cytosolOne of 2 routes

• CHEBI:240943Reach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by AADAT, GLYAT, GLYATL2, GLYATL1mitochondrial matrix

• potassium atomReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. transport of aspartate (cytosol to extracellular)

  Catalysed by SLC7A13, SLC1A7, SLC1A3, SLC1A2 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• phenylacetylglycineReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by AADAT, GLYATcytosolOne of 3 routes

• CHEBI:28666Reach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. LTD4 hydrolysis

  Catalysed by AADATcytosol

• a dicarboxylateReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by PAH, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• K(+)Reach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC7A13, SLC1A7, SLC1A3, SLC1A2 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• Phe-tRNA(Phe)Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by PAH, FARSB, FARSAcytosol

• Gly-tRNA(Gly)Reach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by AADAT, GARS1cytosol

• Asp-tRNA(Asp)Reach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC7A13, DARS1inner side of the membrane, outer side of the membrane, cytosol

• chlorine(.)Reach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by PAH, SLC6A14extracellular space, cytosolOne of 5 routes

• glycocholateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by AADAT, BAATperoxisomeOne of 3 routes

• N-carbamoyl-L-aspartateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC7A13, CADinner side of the membrane, outer side of the membrane

• 5-aminolevulinateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by AADAT, ALAS1, ALAS2

• glycochenodeoxycholateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by AADAT, BAAT

• glycochenodeoxycholic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by AADAT, BAATperoxisomeOne of 3 routes

• glyoxylateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by TAT, AADATOne of 12 routes

• glycolithocholic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by AADAT, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by AADAT, GCATmitochondrial matrix

• (6R)-L-erythro-6,7-dihydrobiopterinReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
  2. (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by TH, PCBD1, PCBD2One of 2 routes

• L-ornithineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of ornithine and phenylalanine (cytosol to extracellular)

  Catalysed by PAH, SLC7A6extracellular space, cytosolOne of 7 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by AADAT, GLDC, GCSHmitochondrial matrix

• sarcosineReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by AADAT, PIPOXOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by AADAT, SHMT1, SHMT2

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-Citrulline:L-aspartate ligase (AMP-forming)

  Catalysed by SLC7A13, ASS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by SLC7A13, ADSS2, ADSS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• L-histidineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by PAH, SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylglycineReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by AADAT, GLYATL3, GLYAT, GLYATL2

• guanidinoacetateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. L-Arginine:glycine amidinotransferase

  Catalysed by AADAT, GATMcytosolOne of 2 routes

• L-methionineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of methionine and phenylalanine (cytosol to extracellular)

  Catalysed by PAH, SLC7A5extracellular space, cytosolOne of 13 routes

• L-tryptophanReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by TH, TPH1, TPH2One of 14 routes

• glutathioneReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by AADAT, GSS

• L-kynurenineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. Transport of L-Kynurenine

  Catalysed by PAH, SLC7A8extracellular space, cytosolOne of 2 routes

• beta-alanineReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)

  Catalysed by SLC7A13, GAD2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• L-alanineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  2. transport of alanine and phenylalanine (cytosol to extracellular)

  Catalysed by PAH, SLC7A5extracellular space, cytosolOne of 13 routes