(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

470 compounds within 3 steps: 36 in 1, 92 in 2, 342 in 3

Three steps

sarcosineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by GLYATL2, FAAH, PM20D1, PIPOXOne of 2 routes
thromboxane A2Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. prostaglandin-endoperoxide synthase (arachidonate)
3. thromboxane A synthase (prostaglandin H2)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 morecytosol, endoplasmic reticulumOne of 2 routes
7,8-dihydrofolateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 more
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Catalysed by GLYATL2, FAAH, PM20D1, SHMT1 and 1 more
(R)-S-lactoylglutathioneReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate and GSH (cytosol to extracellular)
3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 3 moreextracellular space, cytosolOne of 2 routes
1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
Catalysed by LPCAT3, MBOAT7, PLA2G15, ENPP2 and 2 moreOne of 3 routes
(R)-2-hydroxyoctadecanoateReach from here →
1. 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoate + H(+)
3. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O
Catalysed by MBOAT7, DDHD1, FA2H
O-acetyl-(R)-carnitineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. Utilized Transport
3. Acetyl-CoA:carnitine O-acetyltransferase
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 moreendoplasmic reticulum, cytosolOne of 9 routes
ethanolamineReach from here →
1. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)
Catalysed by LPCAT3, PLA2G15, GDPD1One of 4 routes
a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
Catalysed by LPCAT3, PNPLA8, PRDX6, LPCAT4 and 4 moreOne of 4 routes
an N-acylglycineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by GLYATL2, FAAH, PM20D1, GLYATL3 and 1 more
S-formylglutathioneReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate and GSH (cytosol to extracellular)
3. alcohol dehydrogenase (formaldehyde)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 7 moreextracellular space, cytosol
guanidinoacetateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. L-Arginine:glycine amidinotransferase
Catalysed by GLYATL2, FAAH, PM20D1, GATMcytosolOne of 2 routes
L-methionineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. transport of glycine and methionine (cytosol to extracellular)
Catalysed by GLYATL2, FAAH, PM20D1, SLC7A5extracellular space, cytosolOne of 5 routes
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine
Catalysed by LPCAT3, PNPLA8, ASPG
dehydroepiandrosterone 3-sulfateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 2 moreextracellular space, cytosolOne of 2 routes
L-tryptophanReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. transport of glycine and tryptophan (cytosol to extracellular)
Catalysed by GLYATL2, FAAH, PM20D1, SLC7A5extracellular space, cytosolOne of 5 routes
glutathioneReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by GLYATL2, FAAH, PM20D1, GSS
a 1-acyl-sn-glycero-3-phosphateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+)
Catalysed by LPCAT3, PNPLA8, ENPP2One of 2 routes
L-alanineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. transport of alanine and glycine (cytosol to extracellular)
Catalysed by GLYATL2, FAAH, PM20D1, SLC3A2 and 2 moreextracellular space, cytosolOne of 6 routes
leukotriene C4Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of leukotriene C4 (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 2 moreextracellular space, cytosolOne of 10 routes
L-asparagineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. transport of asparagine and glycine (cytosol to extracellular)
Catalysed by GLYATL2, FAAH, PM20D1extracellular space, cytosolOne of 4 routes
L-phenylalanineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 2 moreOne of 8 routes
a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. a 1-acyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by LPCAT3, PNPLA8, LPCAT4
glutathione disulfideReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. Arachidonate:oxygen 5-oxidoreductase
3. Glutathione: 5-HPETE oxidoreductase
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 11 morecytosolOne of 23 routes
taurolithocholate 3-sulfateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 moreextracellular space, cytosolOne of 4 routes
L-tyrosineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
Catalysed by GLYATL2, FAAH, PM20D1, AADAT
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by GLYATL2, FAAH, PM20D1, AGXT2
an acyl-CoAReach from here →
1. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by LPCAT3, LPGAT1cytosolOne of 2 routes
histamineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of histamine (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 moreextracellular space, cytosolOne of 4 routes
1D-myo-inositol 1-phosphateReach from here →
1. 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoate + H(+)
3. 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1D-myo-inositol 1-phosphate + H(+)
Catalysed by MBOAT7, DDHD1, GDPD2
L-thyroxineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 moreextracellular space, cytosolOne of 4 routes
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 1 morecytosol, extracellular spaceOne of 12 routes
S-sulfanylglutathioneReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate and GSH (cytosol to extracellular)
3. Sulfide:glutathione,quinone oxidoreductase
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 2 moreextracellular space, cytosol, mitochondrial matrix
monodehydro-L-ascorbate radicalReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion
3. 8-peroxy-(5Z,9E,11Z,14Z)... to 5,9-cyclo-6,8-cycloperoxy-12... conversion
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 1 morecytosol
dopamineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of dopamine (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 moreextracellular space, cytosolOne of 4 routes
1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by LPCAT3, PNPLA8
glycolithocholate 3-sulfateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 moreextracellular space, cytosolOne of 4 routes
a 2,3-dehydroacyl-CoAReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 more
estrone 3-sulfateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of estrone 3-sulfate (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 2 moreextracellular space, cytosolOne of 2 routes
prostaglandin E2Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate (cytosol to extracellular)
3. transport of prostaglandin E2 (cytosol to extracellular)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 moreextracellular space, cytosolOne of 7 routes
N-benzoylglycineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
3. Hippurate (Benzoylglycinate) Formation
Catalysed by GLYATL2, FAAH, PM20D1mitochondrial matrixOne of 2 routes
1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
3. 2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
Catalysed by LPCAT3, MBOAT7, PLA2G15, ASPG
L-cysteinylglycineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. transport of arachidonate and GSH (cytosol to extracellular)
3. glutathione gamma-glutamylaminopeptidase
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 7 moreextracellular space, cytosolOne of 4 routes
Fe(II)-heme aReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
3. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 4 more
an all-trans-retinyl esterReach from here →
1. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
2. a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)
3. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)
Catalysed by MBOAT7, AGPAT3, DDHD1, RPE65
CHEBI:63544Reach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
2. Arachidonate:CoA ligase (AMP-forming)
3. fatty-acyl-CoA elongation (N-C20:4CoA)
Catalysed by ACOT8, THEM4, THEM5, ACOT4 and 13 morecytosol
a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine = sn-glycerol 3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine
Catalysed by LPCAT3, PNPLA8, ASPGOne of 3 routes
a 1-acyl-sn-glycerolReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H(+)
Catalysed by LPCAT3, PNPLA8, ENPP6
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerolReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by LPCAT3, PNPLA8, TAFAZZIN