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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q8N9F7

GDPD1

Protein·UNIPROT:Q8N9F7Lysophospholipase D GDPD1

Open in the graph

Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl-lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl-lysophosphatidylethanolamin (N-acyl-lysoPE). In addition, hydrolyzes glycerophospho-N-acylethanolamine to N-acylethanolamine. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (By similarity)..

Function from UniProtKB (Q8N9F7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

18 statements

18 statements · 3 reference databases · Subject: GDPD1 · Sources: Hetionet, Reactome, Rhea

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UBC interacts with GDPD1ProteinHetionet hetionet:interacts:284161-7316Inferred only
GDPD1 participates in Glycerophospholipid catabolismPathwayReactome R-HSA-6814848Inferred only
GDPD1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GDPD1 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
GDPD1 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
GDPD1 participates in PI MetabolismPathwayReactome R-HSA-1483255Inferred only
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine is a substrate of GDPD1CompoundRhea RHEA:38915Inferred only
1-hexadecanoyl-sn-glycero-3-phosphocholine is a substrate of GDPD1CompoundRhea RHEA:38975Inferred only
1-hexadecanoyl-sn-glycero-3-phosphoethanolamine is a substrate of GDPD1CompoundRhea RHEA:53172Inferred only
1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine is a substrate of GDPD1CompoundRhea RHEA:53188Inferred only
1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine is a substrate of GDPD1CompoundRhea RHEA:53184Inferred only
1-O-hexadecyl-sn-glycero-3-phosphocholine is a substrate of GDPD1CompoundRhea RHEA:41143Inferred only

Show the remaining 6

a 1-O-alkyl-sn-glycero-3-phosphocholine is a substrate of GDPD1CompoundRhea RHEA:39927Inferred only
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of GDPD1CompoundRhea RHEA:45544Inferred only
N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of GDPD1CompoundRhea RHEA:53168Inferred only
N-hexadecanoyl-sn-glycero-3-phosphoethanolamine is a substrate of GDPD1CompoundRhea RHEA:45436Inferred only
N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of GDPD1CompoundRhea RHEA:56460Inferred only
N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine is a substrate of GDPD1CompoundRhea RHEA:45592Inferred only

Reactions

13 reactions

1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+choline+hydron
Catalysed by ENPP2 or GDPD1
Reaction pageLeft to rightBalanced
Rhea RHEA:38915CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphate+choline+hydron
Catalysed by

Other names

3 names

Resolves to: GDPD1

Also called: GDE4Glycerophosphodiester phosphodiesterase 4Glycerophosphodiester phosphodiesterase domain-containing protein 1

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Reaction pageLeft to rightBalanced

Rhea RHEA:38975CC BY 4.0Reference data

a 1-O-alkyl-sn-glycero-3-phosphocholine+watera 1-O-alkyl-sn-glycero-3-phosphate+choline+hydron

Catalysed by ENPP2 or GDPD1

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:39927CC BY 4.0Reference data

1-O-hexadecyl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycero-3-phosphate+choline+hydron

Catalysed by ENPP2 or GDPD3 or GDPD1

Reaction pageLeft to rightBalanced

Rhea RHEA:41143CC BY 4.0Reference data

N-hexadecanoyl-sn-glycero-3-phosphoethanolamine+waterN-hexadecanoylethanolamine+sn-glycerol 3-phosphate+hydron

Catalysed by GDPD1 or GDE1

Reaction pageLeft to rightBalanced

Rhea RHEA:45436CC BY 4.0Reference data

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine+1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron

Catalysed by NAPEPLD or GDPD3 or GDPD1

Reaction pageLeft to rightBalanced

Rhea RHEA:45544CC BY 4.0Reference data

N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine+waterN-hexadecanoylethanolamine+1-hexadecanoyl-sn-glycero-3-phosphate+hydron

Catalysed by NAPEPLD or GDPD1

Reaction pageLeft to rightBalanced

Rhea RHEA:45592CC BY 4.0Reference data

N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-hexadecanoylethanolamine+1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron

Catalysed by GDPD3 or GDPD1

Reaction pageLeft to rightBalanced

Rhea RHEA:53168CC BY 4.0Reference data

1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphate+ethanolamine+hydron

Catalysed by GDPD1

Reaction pageLeft to rightBalanced

Rhea RHEA:53172CC BY 4.0Reference data

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine+water1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate+N-hexadecanoylethanolamine+hydron

Catalysed by GDPD3 or GDPD1 or GDE1

Reaction pageLeft to rightBalanced

Rhea RHEA:53184CC BY 4.0Reference data

1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine+water1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate+N-(9Z-octadecenoyl) ethanolamine+hydron

Catalysed by GDPD1 or GDE1

Reaction pageLeft to rightBalanced

Rhea RHEA:53188CC BY 4.0Reference data

CHEBI:137016+water1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate+N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine+hydron

Catalysed by GDPD1 or GDE1

Reaction pageLeft to rightBalanced

Rhea RHEA:53192CC BY 4.0Reference data

Show the remaining 1