selenomethionine

Three steps

• formic acidReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-hydroxybutyrate:NAD+ oxidoreductase
  3. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)

  Catalysed by CTH, LDHB, LDHC, LDHAL6A and 5 morecytosol, extracellular spaceOne of 4 routes

• propionic acidReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-hydroxybutyrate:NAD+ oxidoreductase
  3. transport of 2-hydroxybutyrate and propanoate (cytosol to extracellular)

  Catalysed by CTH, LDHB, LDHC, LDHAL6A and 5 morecytosol, extracellular spaceOne of 7 routes

• butyric acidReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-hydroxybutyrate:NAD+ oxidoreductase
  3. transport of 2-hydroxybutyrate and butyrate (cytosol to extracellular)

  Catalysed by CTH, LDHB, LDHC, LDHAL6A and 5 morecytosol, extracellular spaceOne of 4 routes

• 3-hydroxypyruvic acidReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. L-Serine:pyruvate aminotransferase

  Catalysed by CTH, AGXT2, AGXTcytosolOne of 2 routes

• glutarateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by CTH, AADAT, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-oxopropanoateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by CTH, AGXT2cytosol

• 2-oxohexanoateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by CTH, AGXT2cytosol

• D-serineReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. D-serine = pyruvate + NH4(+)

  Catalysed by CTH, AGXT2, SRRcytosol

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by CTH, AGXT2, AADATcytosol

• (R)-lactic acidReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by CTH, AGXT2, LDHDcytosol

• (S)-lactic acidReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-hydroxybutyrate:NAD+ oxidoreductase
  3. transport of 2-hydroxybutyrate and L-lactate (cytosol to extracellular)

  Catalysed by CTH, LDHB, LDHC, LDHAL6A and 8 morecytosol, extracellular spaceOne of 7 routes

• 2-iminopropanoateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by CTH, AGXT2, RIDAcytosol

• phosphoenolpyruvic acidReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. pyruvate kinase (dTDP)

  Catalysed by CTH, AGXT2, PKM, PKLRcytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by CTH, AGXT2, NPLcytosol

• a 3-acylpyruvateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by CTH, AGXT2, FAHD1cytosol

• glycineReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. L-threonine = 2-oxobutanoate + NH4(+)
  3. L-threonine = acetaldehyde + glycine

  Catalysed by CTH, SDS, SDSL, SHMT1cytosolOne of 17 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutyrate oxidation
  3. propanoyl-CoA:carbon-dioxide ligase (ADP-forming)

  Catalysed by CTH, PCCA, PCCBcytosol, mitochondrial matrix

• acryloyl-CoAReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutyrate oxidation
  3. medium-chain acyl-CoA dehydrogenase (propanoyl-CoA)

  Catalysed by CTH, ACADS, ACADSBcytosol, mitochondrial matrix

• 2-oxoadipateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by CTH, AGXT2, AADATcytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by CTH, AGXT2, MPSTcytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by CTH, AGXT2cytosol

• L-methionineReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by CTH, AGXT2, TYW1B, TYW1cytosol

• L-alanineReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. L-threonine = 2-oxobutanoate + NH4(+)
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by CTH, SDS, SDSL, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 23 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O
  3. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate

  Catalysed by CTH, AADAT, AGXT2cytosolOne of 7 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. L-threonine = 2-oxobutanoate + NH4(+)
  3. trans-4-hydroxy-L-proline(out) + L-threonine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-threonine(out) + Na(+)(in)

  Catalysed by CTH, SDS, SDSL, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalyl-CoAReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by CTH, AGXT2, CLYBLcytosol

• 5-amino-2-oxopentanoateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine

  Catalysed by CTH, AGXT2cytosolOne of 2 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by CTH, AGXT2, HOGA1cytosolOne of 2 routes

• xanthurenateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by CTH, AGXT2, KYAT3, AADATcytosol

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by CTH, AGXT2, HOGA1cytosolOne of 2 routes

• L-threonylcarbamoyladenylateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. L-threonine = 2-oxobutanoate + NH4(+)
  3. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O

  Catalysed by CTH, SDS, SDSL, YRDCcytosol

• 3-methylmalateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by CTH, AGXT2, CLYBLcytosol

• Se-methylselenocysteineReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. Selenocystathionine Lysteine-lyase (deaminating)
  3. L-Serine hydro-lyase (adding homocysteine)

  Catalysed by CTH, CBScytosol

• thiamine(1+) diphosphateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)
  3. lipoamide to thiamin-PP conversion

  Catalysed by CTH, BCKDHA, BCKDHB, DBTcytosol, mitochondrial matrix

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. Selenomethionine methanethiol-lyase (deaminating)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by CTH, AGXT2, PDHA1, PDHB and 1 morecytosol, mitochondrial matrix