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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P00156

MT-CYB

Protein·UNIPROT:P00156

Open in the graph

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis..

Function from UniProtKB (P00156), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

Leber hereditary optic neuropathy has a germline basis in MT-CYBDiseaseGenCC HGNC:7427|MONDO:0010788Inferred only
mitochondrial complex III deficiency has a germline basis in MT-CYBDiseaseGenCC HGNC:7427|MONDO:0015448Inferred only
mitochondrial disease has a germline basis in MT-CYBDiseaseGenCC HGNC:7427|MONDO:0044970Inferred only

Statements

16 statements

16 statements · 5 reference databases · Subject: MT-CYB · Sources: Hetionet, Human-GEM, Reactome, UniProt, WikiPathways

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MT-CYB interacts with MVPProteinHetionet hetionet:interacts:4519-9961Inferred only
MT-CYB participates in 16p12 2 copy number variation syndrome 520kb PathwayWikiPathways WP5510Inferred only
MT-CYB participates in Aerobic respiration and respiratory electron transportPathwayReactome R-HSA-1428517Inferred only
MT-CYB participates in Complex III assemblyPathwayReactome R-HSA-9865881Inferred only
MT-CYB participates in Electron transport chain OXPHOS system in mitochondriaPathwayWikiPathways WP111Inferred only
MT-CYB participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
MT-CYB participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
MT-CYB participates in Mitochondrial complex III assemblyPathwayWikiPathways WP4921Inferred only
MT-CYB participates in Mitochondrial translationPathwayReactome R-HSA-5368287Inferred only
MT-CYB participates in Mitochondrial translation terminationPathwayReactome R-HSA-5419276Inferred only
MT-CYB participates in Nonalcoholic fatty liver diseasePathwayWikiPathways WP4396Inferred only
MT-CYB participates in Respiratory electron transportPathwayReactome R-HSA-611105Inferred only

Show the remaining 4

MT-CYB participates in TranslationPathwayReactome R-HSA-72766Inferred only
MT-CYB requires the cofactor heme bCompoundUniProt P00156Inferred only
proton is transported by MT-CYBCompoundHuman-GEM MAR06918Inferred only
proton is transported by MT-CYBCompoundHuman-GEM MAR20189Inferred only

Reactions

2 reactions

2ferricytochrome c+2proton+ubiquinol2ferrocytochrome c+4proton+ubiquinones
Transported by UQCRQ & UQCR11 & MT-CYB & UQCRH & CYC1 & UQCRB & UQCRC2 & UQCRC1 & UQCRFS1 & UQCR10
Reaction pageLeft to rightBalancedEC 7.1.1.8mitochondrial matrix, mitochondrial intermembrane space

Other names

7 names

Resolves to: MT-CYB

Also called: COBComplex III subunit 3Complex III subunit IIICYTBCytochrome b-c1 complex subunit 3MTCYBUbiquinol-cytochrome-c reductase complex cytochrome b subunit

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Human-GEM MAR06918CC BY 4.0Reference data

MAM01329c+2ferricytochrome c+5protonMAM01328c+2ferrocytochrome c+4proton

Transported by UQCRQ & UQCR11 & MT-CYB & UQCRH & CYC1 & UQCRB & UQCRC2 & UQCRC1 & UQCRFS1 & UQCR10

Reaction pageLeft to rightUnbalancedEC 7.1.1.8cytosol, mitochondrial matrix, mitochondrial intermembrane space

Human-GEM MAR20189CC BY 4.0Reference data