(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

117 compounds within 3 steps: 5 in 1, 13 in 2, 99 in 3

Three steps

Met-tRNA(Met)Reach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)
2. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
3. L-Methionine:tRNAMet ligase (AMP-forming)
Catalysed by MTHFR, MTR, MARS1cytosol
4-methylsulfanyl-2-oxobutanoateReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)
2. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine
Catalysed by MTHFR, MTR, AADAT
CHEBI:16856Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
Catalysed by SHMT1, SHMT2, GSScytosol
CHEBI:16857Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glycine and threonine (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 7 routes
glyoxylic acidReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. glycine:oxygen oxidoreductase (deaminating)
Catalysed by SHMT1, SHMT2, DAOperoxisome
L-isoleucineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glycine and isoleucine (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC7A5extracellular space, cytosolOne of 7 routes
CHEBI:17203Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glycine and proline (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC7A5, SLC7A6extracellular space, cytosolOne of 5 routes
AH2Reach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)
2. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
3. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by MTHFR, MTR, CDKAL1One of 3 routes
5-aminolevulinic acidReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
Catalysed by SHMT1, SHMT2, ALAS1, ALAS2 and 1 moremitochondrial matrix
L-cysteineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of cysteine and glycine (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 10 routes
CHEBI:17895Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glycine and tyrosine (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC7A5extracellular space, cytosolOne of 8 routes
CHEBI:18019Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glycine and lysine (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC7A6extracellular space, cytosolOne of 4 routes
triphosphateReach from here →
1. dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP
2. dTTP + H2O = dTMP + diphosphate + H(+)
3. dTTP + H2O = thymidine + triphosphate + H(+)
Catalysed by TYMS, ASMTL, SAMHD1
L-glutamineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glutamine and glycine (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC7A5extracellular space, cytosolOne of 10 routes
N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH
2. 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)
3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase
Catalysed by MTHFD1, MTHFD2L, GARTcytosol
N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
Catalysed by SHMT1, SHMT2, GARTcytosol
CHEBI:18381Reach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)
2. 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in)
3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
Catalysed by MTHFR, SLC19A1, ATICinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
ophthalmateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)
Catalysed by SHMT1, SHMT2, GSS
S-methylmercury-L-cysteineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)
2. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
Catalysed by MTHFR, MTR, SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes
N(omega),N('omega)-dimethyl-L-arginineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by SHMT1, SHMT2, AGXT2
CHEBI:240943Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. glycine N-acyltransferase (2-methylbutyryl-CoA)
Catalysed by SHMT1, SHMT2, GLYAT, GLYATL2 and 1 moremitochondrial matrix
phenylacetylglycineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. phenylacetyl-CoA:glycine N-phenylacetyltransferase
Catalysed by SHMT1, SHMT2, GLYATcytosolOne of 3 routes
CHEBI:28666Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. LTD4 hydrolysis
Catalysed by SHMT1, SHMT2cytosol
Gly-tRNA(Gly)Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. glycine:tRNA(Gly) ligase (AMP-forming)
Catalysed by SHMT1, SHMT2, GARS1cytosol
chlorine(.)Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of chloride and glycine (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC6A9, SLC6A14extracellular space, cytosolOne of 5 routes
glycocholateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by SHMT1, SHMT2, BAATperoxisomeOne of 3 routes
L-aspartateReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)
2. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
3. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
Catalysed by MTHFR, MTR, SLC7A13inner side of the membrane, outer side of the membraneOne of 2 routes
4-methylthio-2-oxobutanoic acidReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)
2. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
3. L-Methionine:oxygen oxidoreductase (deaminating)
Catalysed by MTHFR, MTR, IL4I1cytosol
5-aminolevulinateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA
Catalysed by SHMT1, SHMT2, ALAS1, ALAS2
glycochenodeoxycholateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
Catalysed by SHMT1, SHMT2, BAAT
glycochenodeoxycholic acidReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by SHMT1, SHMT2, BAATperoxisomeOne of 3 routes
glyoxylateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
Catalysed by SHMT1, SHMT2, AADATOne of 11 routes
glycolithocholic acidReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. bile acid-CoA:amino acid N-acyltransferase (glycine)
Catalysed by SHMT1, SHMT2, BAATcytosolOne of 2 routes
L-2-amino-3-oxobutanoic acidReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. Acetyl-CoA:glycine C-acetyltransferase
Catalysed by SHMT1, SHMT2, GCATmitochondrial matrix
phosphoenolpyruvic acidReach from here →
1. dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP
2. dTTP + H2O = dTMP + diphosphate + H(+)
3. pyruvate kinase (dTDP)
Catalysed by TYMS, ASMTL, PKM, PKLRcytosol
L-ornithineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. L-Arginine:glycine amidinotransferase
Catalysed by SHMT1, SHMT2, GATMcytosolOne of 7 routes
S(8)-aminomethyldihydrolipoamideReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)
Catalysed by SHMT1, SHMT2, GLDC, GCSHmitochondrial matrix
2-deoxy-alpha-D-ribose 1-phosphateReach from here →
1. dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP
2. thymidylate 5'-phosphohydrolase
3. thymidine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + thymine
Catalysed by TYMS, ACP3, NT5E, NT5C2 and 8 morecytosol
sarcosineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by SHMT1, SHMT2, PIPOXOne of 2 routes
dCMPReach from here →
1. dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP
2. deoxythymidylate kinase (dADP)
3. cytidine/uridine monophosphate kinase (dADP)
Catalysed by TYMS, DTYMK, CMPK1mitochondrial matrix, cytosolOne of 2 routes
an N-acylglycineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by SHMT1, SHMT2, GLYATL3, GLYAT and 1 more
dGMPReach from here →
1. dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP
2. deoxythymidylate kinase (dADP)
3. dADP to dATP conversion
Catalysed by TYMS, DTYMKmitochondrial matrix
guanidinoacetateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. L-Arginine:glycine amidinotransferase
Catalysed by SHMT1, SHMT2, GATMcytosolOne of 2 routes
L-tryptophanReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glycine and tryptophan (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC7A5extracellular space, cytosolOne of 9 routes
glutathioneReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by SHMT1, SHMT2, GSS
L-alanineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of alanine and glycine (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 13 routes
leukotriene C4Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. leukotriene C4 hydrolysis
Catalysed by SHMT1, SHMT2cytosol
L-asparagineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of asparagine and glycine (cytosol to extracellular)
Catalysed by SHMT1, SHMT2extracellular space, cytosolOne of 7 routes
L-phenylalanineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
3. transport of glycine and phenylalanine (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, SLC7A5extracellular space, cytosolOne of 13 routes
L-homocysteineReach from here →
1. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)
2. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)
Catalysed by MTHFR, MTR, BHMT2