3-sulfinopyruvate

Three steps

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4cytosol

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4cytosol

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4cytosol

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4cytosol

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX4cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by AGXT2cytosol, mitochondrial matrixOne of 3 routes

• (S)-lactoyl-AMPReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 3 morecytosol

• (S)-lactoyl-CoAReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 morecytosol

• N-acetylneuraminate 9-phosphateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. pyruvate kinase (dTDP)
  3. N-acetylneuraminate synthase

  Catalysed by PKM, PKLR, NANScytosol

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by TSTD1, GSTP1cytosol

• a quinolReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by ME2, SDHB, SDHAcytosolOne of 2 routes

• potassium atomReach from here →
  1. 3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. transport of aspartate (cytosol to extracellular)

  Catalysed by GOT1, SLC25A12, SLC25A13, SLC1A7 and 4 moremitochondrial matrix, cytosol, extracellular space

• folic acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Folate Transport by Oats

  Catalysed by SUOX, SLC22A8, SLC22A7cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• selenomethionineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by AGXT2, CTHcytosol

• CHEBI:27760Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by AGXT2, CTHcytosol

• 3-mercaptolactic acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by MPST, LDHB, LDHC, LDHAL6A and 1 morecytosol

• 2-oxopentanoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by AGXT2cytosol

• 17alpha-hydroxypregnenoloneReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular space, endoplasmic reticulum

• pyridoxine 5'-phosphateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by AGXT2, SCLYcytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A35, SLC25A34cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-glycoloylneuraminateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)

  Catalysed by NPLcytosol

• a carboxylateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by FAHD1cytosol

• L-ascorbic acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by TSTD1, CLIC1, GSTO1, GSTO2cytosol

• K(+)Reach from here →
  1. 3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by GOT1, SLC25A12, SLC25A13, SLC1A7 and 4 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Asp-tRNA(Asp)Reach from here →
  1. 3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by GOT1, SLC25A12, SLC25A13, DARS1mitochondrial matrix, cytosol

• chlorine(.)Reach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by AGXT2, SLC6A14cytosol, mitochondrial matrix, extracellular spaceOne of 9 routes

• glycocholateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4cytosol, inner side of the membrane, outer side of the membrane

• cholateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4cytosol, inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by MPSTcytosolOne of 4 routes

• D-aspartateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• oxalateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC26A2, SLC25A30 and 2 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• citric acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by PC, CScytosol, mitochondrial matrixOne of 9 routes

• maleateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• an alcoholReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by TSTD1, CP, PRDX6cytosol

• isocitric acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. pyruvate kinase (dTDP)
  3. transport of isocitrate and PEP (cytosol to mitochondria)

  Catalysed by PKM, PKLR, SLC25A1cytosol, mitochondrial matrixOne of 5 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by PC, GOT2cytosol, mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• cis-aconitic acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. pyruvate kinase (dTDP)
  3. transport of cis-aconitate and PEP (cytosol to mitochondria)

  Catalysed by PKM, PKLR, SLC25A1cytosol, mitochondrial matrixOne of 5 routes

• N-carbamoyl-L-aspartateReach from here →
  1. 3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate
  2. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by GOT1, SLC25A12, SLC25A13, CADmitochondrial matrix, cytosol

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by TYW1B, TYW1, IL4I1cytosol

• 2-oxohexanoateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by AGXT2cytosol

• D-cysteineReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-alpha-aminobutyric acidReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. glutamic-pyruvic transaminase ((S)-2-aminobutanoate)

  Catalysed by AGXT2, GPTcytosol

• glycochenodeoxycholateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4cytosol, inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4cytosol, inner side of the membrane, outer side of the membrane

• glyoxylateReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by ME2, CLYBLcytosolOne of 8 routes

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. 3-sulfinylpyruvic acid hydrolysis
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by HMGCL, HMGCLL1cytosol, mitochondrial matrix