cholesterol sulfate

Three steps

• estroneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by STScytosolOne of 3 routes

• propanoateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by STS, SLC22A9cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• anilineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by STS, SOAT2, SOAT1, NAT2 and 1 morecytosol, endoplasmic reticulum

• CHEBI:17312Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by STS, SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 2 routes

• linoleic acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Acyl-CoA:cholesterol O-acyltransferase
  3. Steryl-ester acylhydrolase

  Catalysed by STS, SOAT2, SOAT1, CEL and 1 morecytosol, endoplasmic reticulum, lysosomeOne of 2 routes

• enol-oxaloacetateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAcytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by STS, SOAT2, SOAT1, NAGScytosol, endoplasmic reticulum, mitochondrial matrixOne of 3 routes

• 3,3'-diiodo-L-thyronineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by STScytosol, Golgi apparatusOne of 3 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by STS, SOAT2, SOAT1, HADHA and 2 morecytosol, endoplasmic reticulum, mitochondrial matrix

• glycine betaineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A12cytosol, extracellular spaceOne of 3 routes

• urateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17895Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• 7alpha-hydroxycholest-4-en-3-oneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. cytochrome P450 (cholesterol)
  3. 7alpha-Hydroxycholesterol:NAD+ 3-oxidoreductase

  Catalysed by STS, CYP7A1, HSD3B7cytosol, endoplasmic reticulumOne of 5 routes

• CHEBI:17927Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by STS, SOAT2, SOAT1cytosol, endoplasmic reticulum

• butanoateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by STS, SLC22A9cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:18019Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular space

• thiocyanateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 3 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by STS, SLC25A10, FAHcytosol, mitochondrial matrix

• L-glutamineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 3 routes

• CHEBI:18095Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by STS, SLC26A6, CLTRN, SLC6A20cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by STS, SLC26A6cytosol, extracellular spaceOne of 2 routes

• hydrogen cyanideReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, MPST and 1 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by STS, SOAT2, SOAT1, HADHA and 2 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by STS, SOAT2, SOAT1, HADHA and 2 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by STS, SOAT2, SOAT1, HADHA and 2 morecytosol, endoplasmic reticulum, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by STS, SOAT2, SOAT1, ECHS1 and 2 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by STS, SOAT2, SOAT1, ECHS1 and 2 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by STS, SLC26A6, SLC6A5cytosol, extracellular spaceOne of 2 routes

• a quinolReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAcytosol, mitochondrial matrix

• hypochlorous acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by STS, SLC26A6, LPOcytosol, extracellular spaceOne of 4 routes

• octadecanoateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Acyl-CoA:cholesterol O-acyltransferase
  3. Steryl-ester acylhydrolase

  Catalysed by STS, SOAT2, SOAT1, CEL and 1 morecytosol, endoplasmic reticulum, lysosomeOne of 2 routes

• potassium atomReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC12A2, SLC12A1cytosol, extracellular spaceOne of 3 routes

• CHEBI:27540Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by STS, SOAT2, SOAT1, ACSM4 and 5 morecytosol, endoplasmic reticulumOne of 6 routes

• 7-dehydrodesmosterolReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. 3-hydroxyacyl-CoA dehydrogenase (desmosterol)
  3. 7-Dehydrocholesterol Reductase

  Catalysed by STS, DHCR7cytosol, nucleus

• elaidic acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 5 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by STScytosolOne of 3 routes

• CHEBI:28701Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by STS, SOAT2, SOAT1, ACAA1 and 2 morecytosol, endoplasmic reticulum, peroxisomeOne of 7 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. cytochrome P450 (cholesterol)
  3. cytochrome P450 (pregnenolone)

  Catalysed by STS, CYP11A1, CYP17A1cytosol, mitochondrial matrixOne of 3 routes

• a fatty acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)

  Catalysed by STS, LCAT, CES1, LIPN and 2 morecytosol

• K(+)Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by STS, SLC25A14, SLC25A30, SLC1A7 and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Asp-tRNA(Asp)Reach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by STS, SLC25A14, SLC25A30, DARS1cytosol, inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC26A4cytosol, extracellular spaceOne of 2 routes

• citric acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by STS, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 10 routes

• (9Z)-octadecenoateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Acyl-CoA:cholesterol O-acyltransferase
  3. Steryl-ester acylhydrolase

  Catalysed by STS, SOAT2, SOAT1, CEL and 1 morecytosol, endoplasmic reticulum, lysosomeOne of 3 routes

• (indol-3-yl)acetateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes