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Proteins/UNIPROT:Q99624
Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity. Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine. The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions. Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity)..
Function from UniProtKB (Q99624), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
133 statements
133 statements · 7 reference databases · Subject: SLC38A3 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
L-alanine+proton+2sodium(1+)L-alanine+proton+2sodium(1+)
Transported by SLC38A5 or SLC38A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05307CC BY 4.0Reference data
8 names
Resolves to: SLC38A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05313CC BY 4.0Reference data
proton+CHEBI:15971+2sodium(1+)proton+CHEBI:15971+2sodium(1+)
Transported by SLC38A3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05335CC BY 4.0Reference data
L-glutamine+proton+sodium(1+)L-glutamine+proton+sodium(1+)
Transported by SLC38A5 or SLC38A3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR06380CC BY 4.0Reference data
L-glutamine+sodium(1+)+hydronL-glutamine+sodium(1+)+hydron
Transported by SLC38A5 or SLC38A3
Reaction pageReversibleBalanced
Rhea RHEA:71127CC BY 4.0Reference data
L-asparagine+sodium(1+)+hydronL-asparagine+sodium(1+)+hydron
Transported by SLC38A5 or SLC38A3
Reaction pageReversibleBalanced
Rhea RHEA:71131CC BY 4.0Reference data
L-histidine+sodium(1+)+hydronL-histidine+sodium(1+)+hydron
Transported by SLC38A5 or SLC38A3
Reaction pageReversibleBalanced
Rhea RHEA:71135CC BY 4.0Reference data