Pathway
phospho-PLA2 pathway
Phospholipase A2 (PLA2) enzymes hydrolyze arachidonic acid (AA) from the sn-2 position of phospholipids. AA is a precursor of eicosanoids, lipid mediators involved in inflammtory responses. PLA2 enzymes function as regulators of phospholipid acyl turnover, either as housekeepers for membrane repair or for the production of imflammatory lipid mediators. There are diverse forms of PLA2 enyzmes including secretory (sPLA2), calcium-independent and cytosolic (cPLA2). The cPLA2 form which mediates arachidonic acid release is annotated here.
REACT:R-HSA-111995Reactome
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: phospho-PLA2 pathway · Sources: Reactome
- MAPK1 participates in phospho-PLA2 pathwayProteinReactome R-HSA-111995Inferred only
- PLA2G4A participates in phospho-PLA2 pathwayProteinReactome R-HSA-111995Inferred only