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Proteins/UNIPROT:P27930
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors..
Function from UniProtKB (P27930), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
117 statements
117 statements · 4 reference databases · Subject: IL1R2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
16 names
Resolves to: IL1R2