Golgi-to-ER retrograde transport

Retrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (reviewed in Lord et al, 2013; Spang et al, 2013; Heffernan and Simpson, 2014). The balance between these two pathways may be influenced cargo type and concentration and membrane composition, though the details remain to be worked out (reviewed in Heffernan and Simpson, 2014).

Summary from Reactome (R-HSA-8856688), read 2026-09-23.