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Proteins/UNIPROT:Q68DD2

PLA2G4F

Protein·UNIPROT:Q68DD2Cytosolic phospholipase A2 zeta

Open in the graph

Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators. Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis. In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs)..

Function from UniProtKB (Q68DD2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

35 statements

35 statements · 8 reference databases · Subject: PLA2G4F · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

PLA2G4F covaries with ESPL1ProteinHetionet hetionet:covaries:255189-9700Inferred only
IL17REL covaries with PLA2G4FProteinHetionet hetionet:covaries:255189-400935Inferred only
MTNAP1 covaries with PLA2G4FProteinHetionet hetionet:covaries:255189-55028Inferred only
PLA2G4F is expressed in colonAnatomyHuman Protein Atlas ENSG00000168907Inferred only
PLA2G4F is expressed in skin of legAnatomyBgee ENSG00000168907Inferred only
PLA2G4F participates in Acyl chain remodelling of PCPathwayReactome R-HSA-1482788Inferred only
PLA2G4F participates in Acyl chain remodelling of PEPathwayReactome R-HSA-1482839Inferred only
PLA2G4F participates in Acyl chain remodelling of PGPathwayReactome R-HSA-1482925Inferred only
PLA2G4F participates in Acyl chain remodelling of PIPathwayReactome R-HSA-1482922Inferred only
PLA2G4F participates in Acyl chain remodelling of PSPathwayReactome R-HSA-1482801Inferred only
PLA2G4F participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
PLA2G4F participates in Hydrolysis of LPCPathwayReactome R-HSA-1483115Inferred only

Show the remaining 23

PLA2G4F participates in Lipid metabolism in senescent cellsPathwayWikiPathways WP5149Inferred only
PLA2G4F participates in MAPK signalingPathwayWikiPathways WP382Inferred only
PLA2G4F participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
PLA2G4F participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
PLA2G4F participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
PLA2G4F participates in Ras signalingPathwayWikiPathways WP4223Inferred only
PLA2G4F requires the cofactor Ca(2+)CompoundUniProt Q68DD2Inferred only
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4FCompoundRhea RHEA:41271Inferred only
1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G4FCompoundHuman-GEM MAR07603Inferred only
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine is a substrate of PLA2G4FCompoundRhea RHEA:40427Inferred only
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G4FCompoundRhea RHEA:40431Inferred only
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine is a substrate of PLA2G4FCompoundRhea RHEA:38783Inferred only
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine is a substrate of PLA2G4FCompoundRhea RHEA:40811Inferred only
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G4FCompoundRhea RHEA:40815Inferred only
1-hexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4FCompoundRhea RHEA:40435Inferred only
1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4FCompoundRhea RHEA:41067Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G4FCompoundHuman-GEM MAR00463Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G4FCompoundHuman-GEM MAR05254Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G4FCompoundHuman-GEM MAR00630Inferred only
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4FCompoundHuman-GEM MAR07615Inferred only
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4FCompoundRhea RHEA:36231Inferred only
a 1,2-diacyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4FCompoundRhea RHEA:15801Inferred only
phosphatidylethanolamine is a substrate of PLA2G4FCompoundHuman-GEM MAR00643Inferred only

Reactions

16 reactions

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and

Other names

2 names

Resolves to: PLA2G4F

Also called: cPLA2-zetaPhospholipase A2 group IVF

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6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4endoplasmic reticulum

Human-GEM MAR00463CC BY 4.0Reference data

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR00630CC BY 4.0Reference data

water+phosphatidylethanolamineMAM00511c+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR00643CC BY 4.0Reference data

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4lysosome

Human-GEM MAR05254CC BY 4.0Reference data

water+1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR07603CC BY 4.0Reference data

a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+waterMAM00549c+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR07615CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron

Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:15801CC BY 4.0Reference data

a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+watera 1-O-alkyl-sn-glycero-3-phosphocholine+a fatty acid+hydron

Catalysed by PLA2G6 or PLA2G4A or PLA2G4F or PLB1 or PAFAH2 or PLA2G4C

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:36231CC BY 4.0Reference data

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+hexadecanoate+hydron

Catalysed by DDHD2 or PLAAT3 or PLA2G4F or PLA2G15 or PLAAT2 or PLAAT4

Reaction pageLeft to rightBalanced

Rhea RHEA:38783CC BY 4.0Reference data

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron

Catalysed by PLA2G6 or PLA2G1B or LCAT or PLA2G4B or PLA2G5 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F or PLA2G4D or PNPLA8 or PLA2G3 and 1 more alternative

Reaction pageLeft to rightBalanced

Rhea RHEA:40427CC BY 4.0Reference data

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron

Catalysed by PLA2G6 or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT1 or PNPLA8 or PLAAT2 or PLA2G3 and 1 more alternative

Reaction pageLeft to rightBalanced

Rhea RHEA:40431CC BY 4.0Reference data

1-hexadecanoyl-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+hexadecanoate+hydron

Catalysed by PLA2G6 or LYPLA1 or LYPLA2 or PLA2G4B or LIPC or CEL or PLA2G4A or PLA2G4E or PLA2G4F or PLB1 or PNPLA7 or GDPD3 and 5 more alternatives

Reaction pageLeft to rightBalanced

Rhea RHEA:40435CC BY 4.0Reference data

Show the remaining 4