Pathway
ADP signalling through P2Y purinoceptor 1
Co-activation of P2Y1 and P2Y12 is necessary for complete platelet activation. P2Y1 is coupled to Gq and helps trigger the release of calcium from internal stores, leading to weak and reversible platelet aggregation. P2Y12 is Gi coupled, inhibiting adenylate cyclase, leading to decreased cAMP, a consequent decrease in cAMP-dependent protein kinase activity which increases cytoplasmic [Ca2+], necessary for activation.
Continue reading
In activated platelets, P2Y12 signaling is required for the amplification of aggregation induced by all platelet agonists including collagen, thrombin, thromboxane, adrenaline and serotonin. P2Y12 activation causes potentiation of thromboxane generation, secretion leading to irreversible platelet aggregation and thrombus stabilization.
What the reference databases state
Statements
24 statements
24 statements · 1 reference database · Subject: ADP signalling through P2Y purinoceptor 1 · Sources: Reactome
- GNA11 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNA14 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNA15 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNAQ participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNB1 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNB2 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNB3 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNB4 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNB5 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNG10 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNG11 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNG12 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
Show the remaining 12
- GNG13 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNG2 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNG3 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNG4 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNG5 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNG7 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNG8 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNGT1 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- GNGT2 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- MAPK14 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- P2RY1 participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only
- PLA2G4A participates in ADP signalling through P2Y purinoceptor 1ProteinReactome R-HSA-418592Inferred only