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Proteins/UNIPROT:Q99487
Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation. Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity)..
Function from UniProtKB (Q99487), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 3 reference databases · Subject: PAFAH2 · Sources: Human-GEM, Reactome, Rhea
12 reactions
a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+waterMAM00549c+acetate+proton
Catalysed by PAFAH1B1 or PAFAH1B3 or PAFAH2 or ASPG or PAFAH1B2
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.47cytosol
Human-GEM MAR07611CC BY 4.0Reference data
6 names
Resolves to: PAFAH2
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.47cytosol
Human-GEM MAR08518CC BY 4.0Reference data
a 1-organyl-2-lyso-sn-glycero-3-phospholipid+a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholinea 1-organyl-2-acetyl-sn-glycero-3-phospholipid+a 1-O-alkyl-sn-glycero-3-phosphocholine
Catalysed by PAFAH2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11048CC BY 4.0Reference data
a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+watera 1-O-alkyl-sn-glycero-3-phosphocholine+acetate+hydron
Catalysed by LCAT or PAFAH1B2 or PLA2G7 or PAFAH1B3 or ASPG or PAFAH2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17777CC BY 4.0Reference data
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+watera 1-O-alkyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G6 or PLA2G4A or PLA2G4F or PLB1 or PAFAH2 or PLA2G4C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36231CC BY 4.0Reference data
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycero-3-phosphocholine+acetate+hydron
Catalysed by PLA2G10 or PLA2G6 or PAFAH1B2 or PLA2G7 or PAFAH1B3 or ABHD3 or PAFAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:40479CC BY 4.0Reference data
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine+a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine+1-O-hexadecyl-sn-glycero-3-phosphocholine
Catalysed by PAFAH2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41396CC BY 4.0Reference data
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine+sphing-4-enine1-O-hexadecyl-sn-glycero-3-phosphocholine+N-(acetyl)-sphing-4-enine+hydron
Catalysed by PAFAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:41408CC BY 4.0Reference data
1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycero-3-phosphocholine+propanoate+hydron
Catalysed by PAFAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:41688CC BY 4.0Reference data
1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycero-3-phosphocholine+butanoate+hydron
Catalysed by PAFAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:41692CC BY 4.0Reference data
1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycero-3-phosphocholine+succinate(2-)+hydron
Catalysed by PAFAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:41696CC BY 4.0Reference data
1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycero-3-phosphocholine+glutarate+hydron
Catalysed by PAFAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:41700CC BY 4.0Reference data