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Proteins/UNIPROT:P0C869

PLA2G4B

Protein·UNIPROT:P0C869Cytosolic phospholipase A2 beta

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Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling..

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[Isoform 3]: Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines..

[Isoform 5]: Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids..

Function from UniProtKB (P0C869), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

42 statements

42 statements · 7 reference databases · Subject: PLA2G4B · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

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PLA2G4B is expressed in cerebellar cortexAnatomyBgee ENSG00000243708Inferred only
PLA2G4B is expressed in cerebellar hemisphereAnatomyBgee ENSG00000243708Inferred only
PLA2G4B is expressed in cerebellumAnatomyBgee ENSG00000243708Inferred only
PLA2G4B is expressed in right hemisphere of cerebellumAnatomyBgee ENSG00000243708Inferred only
CASP1 interacts with PLA2G4BProteinHetionet hetionet:interacts:100137049-834Inferred only
CASP3 interacts with PLA2G4BProteinHetionet hetionet:interacts:100137049-836Inferred only
CASP7 interacts with PLA2G4BProteinHetionet hetionet:interacts:100137049-840Inferred only
CASP8 interacts with PLA2G4BProteinHetionet hetionet:interacts:100137049-841Inferred only
PLA2G4B participates in Acyl chain remodelling of PCPathwayReactome R-HSA-1482788Inferred only
PLA2G4B participates in Acyl chain remodelling of PEPathwayReactome R-HSA-1482839Inferred only
PLA2G4B participates in Acyl chain remodelling of PGPathwayReactome R-HSA-1482925Inferred only
PLA2G4B participates in Acyl chain remodelling of PSPathwayReactome R-HSA-1482801Inferred only

Show the remaining 30

PLA2G4B participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
PLA2G4B participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
PLA2G4B participates in Eicosanoid metabolism via cyclooxygenases COX PathwayWikiPathways WP4719Inferred only
PLA2G4B participates in Eicosanoid synthesisPathwayWikiPathways WP167Inferred only
PLA2G4B participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
PLA2G4B participates in Hydrolysis of LPCPathwayReactome R-HSA-1483115Inferred only
PLA2G4B participates in IRE1alpha activates chaperonesPathwayReactome R-HSA-381070Inferred only
PLA2G4B participates in MAPK signalingPathwayWikiPathways WP382Inferred only
PLA2G4B participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
PLA2G4B participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
PLA2G4B participates in Omega 3 omega 6 fatty acid synthesisPathwayWikiPathways WP4723Inferred only
PLA2G4B participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
PLA2G4B participates in Ras signalingPathwayWikiPathways WP4223Inferred only
PLA2G4B participates in Synthesis of PAPathwayReactome R-HSA-1483166Inferred only
PLA2G4B participates in Unfolded Protein Response (UPR)PathwayReactome R-HSA-381119Inferred only
PLA2G4B participates in XBP1(S) activates chaperone genesPathwayReactome R-HSA-381038Inferred only
PLA2G4B requires the cofactor Ca(2+)CompoundUniProt P0C869Inferred only
1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G4BCompoundHuman-GEM MAR07603Inferred only
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine is a substrate of PLA2G4BCompoundRhea RHEA:40427Inferred only
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine is a substrate of PLA2G4BCompoundRhea RHEA:40571Inferred only
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G4BCompoundRhea RHEA:40431Inferred only
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G4BCompoundRhea RHEA:40815Inferred only
1-hexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4BCompoundRhea RHEA:40435Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G4BCompoundHuman-GEM MAR00463Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G4BCompoundHuman-GEM MAR05254Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G4BCompoundHuman-GEM MAR00630Inferred only
a 1-acyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4BCompoundRhea RHEA:15177Inferred only
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4BCompoundHuman-GEM MAR07615Inferred only
a 1,2-diacyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4BCompoundRhea RHEA:15801Inferred only
phosphatidylethanolamine is a substrate of PLA2G4BCompoundHuman-GEM MAR00643Inferred only

Reactions

13 reactions

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and

Other names

3 names

Resolves to: PLA2G4B

Also called: cPLA2-betaLysophospholipase A1 group IVBPhospholipase A2 group IVB

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6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4endoplasmic reticulum

Human-GEM MAR00463CC BY 4.0Reference data

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR00630CC BY 4.0Reference data

water+phosphatidylethanolamineMAM00511c+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR00643CC BY 4.0Reference data

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4lysosome

Human-GEM MAR05254CC BY 4.0Reference data

water+1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR07603CC BY 4.0Reference data

a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+waterMAM00549c+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR07615CC BY 4.0Reference data

a 1-acyl-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+a fatty acid+hydron

Catalysed by PLA2G6 or PLA2G4B or LIPC or PLA2G4A or PLB1 or PNPLA7 or ASPG or PNPLA6 or PLA2G15 or PNPLA8 or PLA2G4C

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:15177CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron

Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:15801CC BY 4.0Reference data

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron

Catalysed by PLA2G6 or PLA2G1B or LCAT or PLA2G4B or PLA2G5 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F or PLA2G4D or PNPLA8 or PLA2G3 and 1 more alternative

Reaction pageLeft to rightBalanced

Rhea RHEA:40427CC BY 4.0Reference data

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron

Catalysed by PLA2G6 or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT1 or PNPLA8 or PLAAT2 or PLA2G3 and 1 more alternative

Reaction pageLeft to rightBalanced

Rhea RHEA:40431CC BY 4.0Reference data

1-hexadecanoyl-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+hexadecanoate+hydron

Catalysed by PLA2G6 or LYPLA1 or LYPLA2 or PLA2G4B or LIPC or CEL or PLA2G4A or PLA2G4E or PLA2G4F or PLB1 or PNPLA7 or GDPD3 and 5 more alternatives

Reaction pageLeft to rightBalanced

Rhea RHEA:40435CC BY 4.0Reference data

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron

Catalysed by PLA2G4B or PLAAT3 or PNPLA8 or PLAAT2 or PLAAT4 or PLA2G4C

Reaction pageLeft to rightBalanced

Rhea RHEA:40571CC BY 4.0Reference data

Show the remaining 1