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Proteins/UNIPROT:Q9BZM2

PLA2G2F

Protein·UNIPROT:Q9BZM2Group IIF secretory phospholipase A2

Open in the graph

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines. May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity)..

Function from UniProtKB (Q9BZM2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

25 statements

25 statements · 6 reference databases · Subject: PLA2G2F · Sources: gene ontology, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

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PLA2G2F participates in Acyl chain remodelling of PCPathwayReactome R-HSA-1482788Inferred only
PLA2G2F participates in Acyl chain remodelling of PEPathwayReactome R-HSA-1482839Inferred only
PLA2G2F participates in Acyl chain remodelling of PGPathwayReactome R-HSA-1482925Inferred only
PLA2G2F participates in Acyl chain remodelling of PIPathwayReactome R-HSA-1482922Inferred only
PLA2G2F participates in Acyl chain remodelling of PSPathwayReactome R-HSA-1482801Inferred only
PLA2G2F participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
PLA2G2F participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
PLA2G2F participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
PLA2G2F participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
PLA2G2F participates in Ras signalingPathwayWikiPathways WP4223Inferred only
PLA2G2F participates in Synthesis of PAPathwayReactome R-HSA-1483166Inferred only
PLA2G2F regulates negative regulation of T cell proliferationBiological processgene ontology Q9BZM2|GO:0042130Inferred only

Show the remaining 13

PLA2G2F requires the cofactor Ca(2+)CompoundUniProt Q9BZM2Inferred only
1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G2FCompoundHuman-GEM MAR07603Inferred only
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G2FCompoundRhea RHEA:40431Inferred only
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) is a substrate of PLA2G2FCompoundRhea RHEA:40919Inferred only
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine is a substrate of PLA2G2FCompoundRhea RHEA:41752Inferred only
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine is a substrate of PLA2G2FCompoundRhea RHEA:38779Inferred only
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G2FCompoundRhea RHEA:40815Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G2FCompoundHuman-GEM MAR05254Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G2FCompoundHuman-GEM MAR00630Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G2FCompoundHuman-GEM MAR00463Inferred only
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine is a substrate of PLA2G2FCompoundHuman-GEM MAR07615Inferred only
a 1,2-diacyl-sn-glycero-3-phosphocholine is a substrate of PLA2G2FCompoundRhea RHEA:15801Inferred only
phosphatidylethanolamine is a substrate of PLA2G2FCompoundHuman-GEM MAR00643Inferred only

Reactions

12 reactions

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and

Other names

3 names

Resolves to: PLA2G2F

Also called: GIIF sPLA2Phosphatidylcholine 2-acylhydrolase 2FsPLA2-IIF

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6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4endoplasmic reticulum

Human-GEM MAR00463CC BY 4.0Reference data

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR00630CC BY 4.0Reference data

water+phosphatidylethanolamineMAM00511c+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR00643CC BY 4.0Reference data

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4lysosome

Human-GEM MAR05254CC BY 4.0Reference data

water+1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR07603CC BY 4.0Reference data

a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+waterMAM00549c+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR07615CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron

Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:15801CC BY 4.0Reference data

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(9Z)-octadecenoate+hydron

Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PLA2G5 or PLAAT3 or PLB1 or PLA2G4D or PLA2G15 or PLA2G2F or PNPLA8 or PLAAT2 and 4 more alternatives

Reaction pageLeft to rightBalanced

Rhea RHEA:38779CC BY 4.0Reference data

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron

Catalysed by PLA2G6 or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT1 or PNPLA8 or PLAAT2 or PLA2G3 and 1 more alternative

Reaction pageLeft to rightBalanced

Rhea RHEA:40431CC BY 4.0Reference data

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(9Z,12Z)-octadecadienoate+hydron

Catalysed by PLA2G10 or PLA2G1B or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT2 or PLA2G3 or PLA2G2E and 2 more alternatives

Reaction pageLeft to rightBalanced

Rhea RHEA:40815CC BY 4.0Reference data

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)+water1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)+(9Z)-octadecenoate+hydron

Catalysed by ABHD16A or PLA2G1B or PLA2G2A or PLB1 or PLA2G15 or PLA2G2F or PLA2G2D

Reaction pageLeft to rightBalanced

Rhea RHEA:40919CC BY 4.0Reference data

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine+water1-hexadecanoyl-sn-glycero-3-phospho-L-serine+(9Z)-octadecenoate+hydron

Catalysed by PLA2G10 or ABHD16A or PLA2G2F

Reaction pageLeft to rightBalanced

Rhea RHEA:41752CC BY 4.0Reference data