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Proteins/UNIPROT:O95470
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity)..
Function from UniProtKB (O95470), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
106 statements
106 statements · 8 reference databases · Subject: SGPL1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
O-phosphoethanolamine+hexadecanalsphinganine 1-phosphate
Catalysed by SGPL1
Reaction pageLeft to rightBalancedEC 4.1.2.27cytosol
Human-GEM MAR00748CC BY 4.0Reference data
sphingosine 1-phosphateO-phosphoethanolamine+(2E)-hexadecenal
Catalysed by SGPL1
Reaction pageLeft to rightBalancedEC 4.1.2.27cytosol
Human-GEM MAR00779CC BY 4.0Reference data
6 names
Resolves to: SGPL1
Catalysed by SGPL1
Reaction pageLeft to rightBalancedEC 4.1.2.27endoplasmic reticulum
Human-GEM MAR08237CC BY 4.0Reference data
water+sphingosine 1-phosphateO-phosphoethanolamine+proton+hexadecanoic acid
Catalysed by SGPL1
Reaction pageLeft to rightBalancedEC 4.1.2.27endoplasmic reticulum
Human-GEM MAR08238CC BY 4.0Reference data
sphinganine 1-phosphatehexadecanal+phosphoethanolamine
Catalysed by SGPL1
Reaction pageLeft to rightBalanced
Rhea RHEA:18593CC BY 4.0Reference data
sphing-4-enine 1-phosphate(2E)-hexadecenal+phosphoethanolamine
Catalysed by SGPL1
Reaction pageLeft to rightBalanced
Rhea RHEA:33507CC BY 4.0Reference data